Purchase this article with an account.
Sander R Dubovy, Maria Paula Fernandez, Antonio Bermudez, Nathan Blessing, Andrew E. Rosenberg; Orbital Solitary Fibrous Tumor of the Orbit: Case Series with Clinicopathological Correlation. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2419.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To report the clinicopathologic findings of 22 cases presenting with solitary fibrous tumor (SFT) of the orbit.
In a non-comparative, consecutive case series, the database at the Florida Lions Ocular Pathology Laboratory was searched for surgical specimens diagnosed with SFT on microscopic examination from 1998 to 2015. The clinicopathologic features of the specimens were evaluated.
The diagnosis of SFT was established by microscopic examination of formalin fixed, paraffin embedded tissue from 22 orbital lesions (Right = 8, Left = 14). Of this group, 13 patients were females and 9 patients were males. The age of presentation ranged from 14 to 84 years. The mean age of presentation was 43. Findings on clinical presentation were lid swelling (N=15,68%), proptosis (N=10, 45%), headache (N=3, 13%), (N=3, 13%), decreased visual acuity (N=1, 0.045%), diplopia (N=1, 0.045%) and pain (N=6, 27%). Symptom duration ranged from 5 days to 2 years. Exophthalmos ranged from 1.0 to 7.0 mm with an average of 5.0 mm. Ultrasound was performed on nine cases. Findings showed low reflectivity in six cases, medium reflectivity in one case and high reflectivity in one case. Ten of the cases were found in an extraconal location and three were found in an intraconal location. Nine were located in the superonasal quadrant, two in the inferonasal quadrant and three in the superotemporal quadrant. On histopathological examination, all demonstrated a well circumscribed spindle cell lesion with bland cytoplasm and lack of prominent nucleoli. On immunohistochemistry, 18 cases were S100 negative and 17 cases were CD34 negative. Four cases showed recurrence of the lesion, but none demonstrated malignant features or malignant clinical behavior.
SFT's are benign, spindle cell lesions most commonly found in the pleura. They have also been reported at extrapleural locations such as the orbit. SFT's arising from the orbit are relatively rare with approximately 50 cases reported in the literature. Herein we present 22 cases of orbital SFT. In our study, SFT occurred in varied age groups, predominantly in adults, with a slight female predominance. Most cases presented with lid swelling and proptosis. On histopathological examination, all were found to be well-circumscribed spindle cell lesions. SFT should be considered in the setting of well circumscribed lesions in patients with lid swelling and proptosis.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
This PDF is available to Subscribers Only