September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Heritability of 10-year longitudinal changes of axial length in Guangzhou Twin Eye Study
Author Affiliations & Notes
  • Zhuoting Zhu
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Jian Zhang
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Mingguang He
    Zhongshan Ophthalmic Center, Guangzhou, China
    University of Melbourne, Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Zhuoting Zhu, None; Jian Zhang, None; Mingguang He, None
  • Footnotes
    Support  National Science Foundation of China Grant 30772393
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2496. doi:
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      Zhuoting Zhu, Jian Zhang, Mingguang He; Heritability of 10-year longitudinal changes of axial length in Guangzhou Twin Eye Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2496.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the heritability of 10-year longitudinal changes of axial length in Guangzhou Twin Eye Study.

Methods : A twin study of the cohort of Guangzhou Twin Eye Study (N=1308 pairs) aged 6-19 years at baseline was conducted annually and followed up for 10 years. Axial length was obtained from partial coherence laser interferometry. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by linear growth curve model adjusting for age and sex.

Results : Linear growth curve models revealed a substantial genetic influence on axial length at baseline (heritability (h2) 91% (95% confidence interval 0.89–0.92) and a high influence on rate of change in axial length (h2 = 87% (0.84 - 0.90). The genetic correlation between baseline and rate of change in axial length was -0.029.

Conclusions : Our results provide a basis for identifying high genetic effects on axial length at baseline and longitudinal changes.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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