September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Cigarette smoking increases intraocular pressure and risk of primary open-angle glaucoma: a systematic review and meta-analysis
Author Affiliations & Notes
  • Shi Song Rong
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Lok Yee Tsui
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Li Ma
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Jian Li
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Chi Pui Calvin Pang
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Li Jia Chen
    Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Footnotes
    Commercial Relationships   Shi Song Rong, None; Lok Yee Tsui, None; Li Ma, None; Jian Li, None; Chi Pui Pang, None; Li Jia Chen, None
  • Footnotes
    Support  Nil
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2576. doi:
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      Shi Song Rong, Lok Yee Tsui, Li Ma, Jian Li, Chi Pui Calvin Pang, Li Jia Chen; Cigarette smoking increases intraocular pressure and risk of primary open-angle glaucoma: a systematic review and meta-analysis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2576.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the effects of cigarette smoking on intraocular pressure (IOP) and risk of primary open-angle glaucoma (POAG), using systematic review and meta-analysis.

Methods : We searched in the MEDLINE and EMBASE databases using structured search strategies. Cross-sectional studies, cohort studies and randomized controlled trials that investigated the association between cigarette smoking and IOP and/or the risk of POAG were included into the meta-analysis. Mean difference (MD) in IOP and summary odds ratio (OR) for the risk of POAG between subjects with and without smoking habit/history were calculated using the fixed-effect model if there was mild inter-study heterogeneity (I2≤25% and P for Q statistics >0.05); otherwise, the random-effect model was used. We assessed the quality of each study and performed sensitivity analysis to assess the robustness of the results.

Results : Among the 681 citations yielded from our search, the effects of smoking on IOP and the risk of POAG were evaluated in 14 and 27 studies, respectively, involving a total of 172,314 subjects. The meta-analysis showed that smokers (current and former) had a higher mean IOP than non-smokers (MD~1.3 mmHg; P<5×10-10; I2=60%). Moreover, current smokers had an increased risk of POAG (OR~1.2; P<0.05; I2=21%), comparing with former (OR=1.08; P>0.2; I2=7%) and any smokers (OR=1.07; P>0.4; I2=56%). Begg's funnel plots and Egger's test showed there was no significant publication bias, and the sensitivity analysis revealed that the results were robust.

Conclusions : Cigarette smoking is associated with an increased IOP and risk of POAG.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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