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Assel Talaspayeva, Albert S Khouri, Neilya Ahmetovna Aldasheva; Central cornea thikness (CCT) discrepancies in Kazakh healthy and POAG patients .. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2604.
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© ARVO (1962-2015); The Authors (2016-present)
Central corneal thickness as a risk factor for glaucoma was well established in the OHTS. The purpose was to identify differences of central corneal thickness (CCT) between a healthy Kazakh population and Kazakhs with primary open-angle glaucoma (POAG) .
Data from healthy Kazakh (N= 51) and Kazakh with confirmed POAG (N= 48) age 40 -70 yr were collected. Visual acuity, refraction, IOP (non contact tonometer, Tomey FT -1000), slit lamp and fundus examination, ultrasound biometry of the lens, vitreous (OcuScan, Alcon), visual field (HFI 750i, Carl Zeiss), and Anterior Segment ASOCT (Visante, Germany) were obtained. Central corneal thickness parameters were measured and analyzed.
On ASOCT in Kazakh healthy subjects CCT averaged 523.1μm ± 0,05 mm. In Kazakhs with early stage of POAG- CCT averaged 517μm ±0,03; while in subjects with severe stage of POAG CCT averaged 508μm ±0,05 . IOP in healthy Kazakhs averaged 15.6 ± 0.2 mm vs subjects with POAG 25.4 ± 0.8 mm. In patients with CCT less than 508 μm the frequency of developing severe stage of POAG was much higher than in patients with thicker cornea ( 11 patients out of 48 ( 5.28%)). The average MD of the visual field in patients with POAG (advanced stage) was −18.3±4.3 vs healthy groups −0.5±1.8. The C/D area ratio of the glaucoma group was significantly greater than that of the healthy group, (P<0.01). The mean RNFL of the glaucoma patients was significantly thinner than that of the healthy patients (P<0.01).
These findings identified differences of CCT between Kazakhs and reported Caucasian CCT. In the Kazakh population with POAG CCT was even thinner than in healthy Kazakh subjects. All of these factors should be taken into account when caring for glaucoma patients of Kazakh decent.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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