September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Increased Stroke Risk among Patients with Open-Angle Glaucoma: A 10-Year Follow-up Cohort Study
Author Affiliations & Notes
  • Sang Yeop Lee
    Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Tyler Hyungtaek Rim
    Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Hee Jung Kwon
    Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Korea (the Republic of)
  • Hyoung Won Bae
    Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Chan Yun Kim
    Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Sang Yeop Lee, None; Tyler Hyungtaek Rim, None; Hee Jung Kwon, None; Hyoung Won Bae, None; Chan Yun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2615. doi:
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      Sang Yeop Lee, Tyler Hyungtaek Rim, Hee Jung Kwon, Hyoung Won Bae, Chan Yun Kim; Increased Stroke Risk among Patients with Open-Angle Glaucoma: A 10-Year Follow-up Cohort Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2615.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : Although several studies showed the correlation between the stroke and open angle glaucoma (OAG), there have not been enough large population based longitudinal studies. In this study, we investigated the risk of subsequent stroke development after initial OAG diagnosis over a 10-year follow-up period.

Methods : We performed a retrospective nationwide propensity score-matched cohort study. OAG and comparison groups were selected from a large database from the Korean National Health Insurance Service, comprising 1,025,340 random subjects. The OAG group comprised patients with an initial diagnosis of OAG between January 2004 and December 2007 (n = 1,520), and the comparison group comprised randomly selected patients (five per glaucoma patient; n = 7,570). Patients who were diagnosed with stroke before the enrollment date were excluded. Each cohort was tracked until 2013 for stroke development. Cox proportional hazard regression analysis was performed to determine possible association.

Results : OAG was associated with increased stroke incidence (HR = 1.20). Hypertension, diabetes mellitus, chronic renal failure, atrial fibrillation, hyperlipidemia, increasing age, and male gender also increased the incidences of stroke. Risk of stroke for OAG patients was greater in the older age group (≥ 65 years, HR = 1.23) than in the younger age group (< 65 years, HR = 1.12), and greater in males (HR = 1.31) than in females (HR = 1.10).

Conclusions : Patients who were diagnosed with OAG were more likely to experience subsequent stroke than comparison groups without OAG, and the risk was greater for older adults and males.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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