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Kunyong Xu, Vasudha Gupta, Steven Bae, Sanjay Sharma; Metamorphopsia and vision-related quality of life among patients with age-related macular degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 2016;57(12):2660.
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© ARVO (1962-2015); The Authors (2016-present)
1) To quantify metamorphopsia; 2) to assess vision-related quality of life (QoL); and 3) to investigate the correlation between metamorphopsia and QoL among patients with AMD.
AMD patients at the Department of Ophthalmology, Hotel Dieu Hospital, were invited to participate in this cross-sectional study. Patients who had a best corrected visual acuity (BCVA) less than 20/200, vitreomacular adhesion, vitreomacular traction, epiretinal membrane, macular hole, macular edema by causes other than AMD, diabetic retinopathy, retinal detachment, previous retinal surgery, glaucoma, amblyopia, or strabismus were excluded. M-CHARTS (Inami, Japan) was used to quantify the minimum visual angle of a dotted line needed to detect metamorphopsia. The examination distance was 30 centimeters, and the refraction of the eye was adjusted to this distance. Metamorphopsia was scored horizontally (MH) and vertically (MV). The mean values of three repeated examinations were used for data analysis. The 25-item National Eye Institute Visual Functioning Questionnaire (VFQ-25) was used to assess vision-related QoL.
30 eyes (53.3% wet AMD and 46.7% dry AMD) of 30 patients were included. Patients were Caucasian (100%) and female predominant (63.3%) with a mean age of 77.0 years (SD= 8.30). The BCVA for near and for distance was 0.50 logMAR (SD=0.27) and 0.49 logMAR (0.25), respectively. The mean score for MV and MH was 0.37 (SD=0.27) and 0.40 (SD=0.32), respectively. The mean score for VFQ-25 was 83.4 (SD= 13.5). Subscales of VFQ-25 with lower mean scores included general health (61.7, SD=23.4), general vision (74.7, SD=11.7), near vision (75.6, SD=20.2), vision-related mental health (79.8, SD=12.4), and distance vision (81.8, SD=20.2). The MV (r1) and MH (r2) scores were correlated with the mean score of VFQ-25 (Spearman rank correlation: r1=-0.39, p=0.0341; and r2=-0.40, p=0.0265, respectively). In addition, MV and MH scores were negatively correlated with VFQ-25 subscales, such as near vision, distance vision, social function, mental health, and peripheral vision.
In our study, AMD patients had slightly higher horizontal versus vertical metamorphopsia quantified using M-CHARTS. The most commonly affected QoL included general health, general vision, near vision, mental health, and distance vision. Quantified metamorphosia and QoL among AMD patients were negatively correlated.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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