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Komal Joshi, Peter L Nesper, Amani A Fawzi, Rukhsana Mirza; OCT Angiography in Adult Onset Foveomacular Vitelliform Dystrophy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2704.
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© 2017 Association for Research in Vision and Ophthalmology.
To describe findings of Adult-Onset Foveomacular Vitelliform Dystrophy (AOFVD) on Optical Coherence Tomography Angiography.
Case series of eight consecutive patients (14 eyes) with AOFVD. Patients were studied with Spectral Domain Optical Coherence Tomography (SD-OCT) and OCT Angiography. OCT Angiography images were obtained using the RTVue-XR Avanti system (Optovue Inc., Femont, California) with split-spectrum amplitude-decorrelation angiography (SSADA) software. Main Outcome measures were presence or absence of choroidal neovascularization and any unifying patterns that could be identified on OCT angiography for AOFVD.
Eight consecutive patients (14 eyes) were studied with SD-OCT and OCT angiography. Patients with clinical exam findings consistent with AOFVD received SD-OCT. Eyes with hyper-reflective material above the RPE and below the Inner Segment/Outer Segment layer, consistent with vitelliform lesion on SD-OCT were further analyzed with OCT angiography. 1 of 14 eyes (7%) had Choroidal Neovascularization under the vitelliform lesion on OCT angiography. 9 of 14 eyes (64%) had shadowing of superficial/deep capillary plexus onto the outer retina giving the false appearance of choroidal neovasculariztion in the region of the vitelliform lesion. All 14 eyes (100%) had blockage of flow signal under the vitelliform lesion that presented as artifactual loss of choriocapillaris under the vitelliform lesion.
OCT angiography can be used as a non-invasive imaging modality to visualize choroidal neovascularization in AOFVD. There are common artifacts that must be considered when analyzing OCT angiography with vitelliform lesions, including shadowing of superficial retinal vessels onto the outer retina and blockage of signal giving the appearance of lost choriocapillaris under the vitelliform lesion.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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