September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Anthocyanin-rich Rhynchosia nulubilis extracts protect photoreceptor cell against MNU-induced retinal degeneration
Author Affiliations & Notes
  • Tae-Jin Kim
    Korea Institute of Science and Technology, Gangneung, Korea (the Republic of)
  • Kyung-A Kim
    Korea Institute of Science and Technology, Gangneung, Korea (the Republic of)
    Department of Biological Chemistry, University of Science and Technology, Daejeon, Korea (the Republic of)
  • Suk Woo Kang
    Korea Institute of Science and Technology, Gangneung, Korea (the Republic of)
  • Kui Dong Kang
    Department of Ophthalmology, St. Mary's Hospital, The Catholic University of Korea, Inchen, Korea (the Republic of)
  • Su Ah Kim
    Department of Ophthalmology, SahmYook Medical Center, Seoul, Korea (the Republic of)
  • Man Jae Kwon
    Korea Institute of Science and Technology, Gangneung, Korea (the Republic of)
  • Sang Hoon Jung
    Korea Institute of Science and Technology, Gangneung, Korea (the Republic of)
    Department of Biological Chemistry, University of Science and Technology, Daejeon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Tae-Jin Kim, None; Kyung-A Kim, None; Suk Woo Kang, None; Kui Dong Kang, None; Su Ah Kim, None; Man Jae Kwon, None; Sang Hoon Jung, None
  • Footnotes
    Support  Korea Institute of Science and Technology (KIST) intramural grant (2Z04381)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2742. doi:
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      Tae-Jin Kim, Kyung-A Kim, Suk Woo Kang, Kui Dong Kang, Su Ah Kim, Man Jae Kwon, Sang Hoon Jung; Anthocyanin-rich Rhynchosia nulubilis extracts protect photoreceptor cell against MNU-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2742.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study is to evaluate the effect of ethanol extract of Rhynchosia nulubilis (EERN) on retinal damage in mice.

Methods : Retinal damage was induced by intraperitoneal injection of N-methyl-N-nitrosourea (MNU) that causes photoreceptor damage. The mice received EEDK daily by gavage for 1 and 4 weeks after MNU injection. Retinas were examined histologically and morphometrically to determine retinal thickness, photoreceptor cell, and retinal damage. Expression of glial fibrillary acidic protein (GFAP), nestin, and rhodopsin protein was assessed by western blotting and immunohistochemistry.

Results : EERN markedly reduced up-regulation of GFAP and nestin. Moreover, EERN up-regulated expression of rhodopsin against retinal damage. Morphologically, the outer nuclear layer, where photoreceptors reside, was well preserved in the EERN-treated mice retinas throughout the experimental period.

Conclusions : These results demonstrate that EERN has protective effects against MNU-induced retinal damage, and may be considered as an agent for treating or preventing retinal degeneration.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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