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Uday B Kompella; Fluidics: Drivers for selective drug delivery into the eye. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
While the rate-limiting nature of ocular epithelial (e.g., cornea and conjunctiva) and vascular tissues (e.g., blood-retinal barrier) for ocular drug delivery is relatively well investigated and understood, the dynamic barriers or fluidics within the eye, are less investigated but equally important in limiting ocular drug delivery. The fluidics within the eye including tear flow, production, elimination, and flow of aqueous humor, creeping flow of aqueous fluid through the vitreous, and blood and lymphatic circulations in conjunction with the tissue barriers dictate drug delivery and distribution within the eye. Similar to tissue barriers, it can be anticipated that the fluidics within the eye can be altered during pathology, potentially resulting in changes in drug delivery. The purpose of this presentation is to summarize some well understood influences and unknowns in terms of ocular fluidics and drug delivery.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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