September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Adaptive Optics Scanning Light Ophthalmoscopy Microangiography
Author Affiliations & Notes
  • Richard B Rosen
    Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Richard Rosen, Allergan (C), Clarity (C), Genetech (F), Nano Retina (C), Ocata (C), OD-OS (S), Opticology (P), Optovue (C), Regeneron (C)
  • Footnotes
    Support  Marrus Family Foundation, Wise Family Foundation, Lowenstein Foundation, New York Eye and Ear Chairman’s Research Fund, Dennis Gierhart Charitable Fund, Violet Fund, NEI U01 EY025477-01, Milbank Foundation, Research to Prevent Blindness 
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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    • Get Citation

      Richard B Rosen; Adaptive Optics Scanning Light Ophthalmoscopy Microangiography. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Adaptive optics scanning light ophthalmoscopy currently offers 2 micron lateral resolution, which is 10 times that achieved with conventional imaging devices, permitting unparalleled in vivo viewing of the microvasculature of the retina. It is possible to see the lamellar details of vessel walls, including deposits on the inner luminal surfaces, structural features of capillaries, such as microaneurysmal dilations, and even individual cells, such as pericytes and red blood cells. A variety of confocal and non-confocal optical techniques, including offset pinhole, split-detection, motion contrast and fluorescein contrast-enhancement in both static and dynamic modes provide complementary perspectives which can help identify perfused and non-perfused capillary segments and blood flow anomalies. Quantitive analysis techniques can be used to reveal subtle evidence of microvascular change and longitudinal studies can provide dynamic near-histological details of the sequence of microangiopathic developments

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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