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Archana Boga, Blanka Golebiowski, Fiona Stapleton; Development of the 2-item Daily Ocular Symptoms Survey to assess day-to-day fluctuations in discomfort and dryness. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2857.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Variation in hormone levels may be important in the increased prevalence of dry eye in women. Daily monitoring of ocular symptoms over a complete menstrual cycle could help understand the role of hormonal variations in women. Thisstudy aimed to develop a short daily ocular symptoms survey (DOSS) and validate it against existing dry eye questionnaires in normally menstruating women. Secondary aims were to examine the effects of oral contraceptive pill (OCP) and phase of menstrual cycle on ocular symptom scores.
Methods: A single-visit cross-sectional online study was conducted on 30 normally menstruating women aged 18 to 43. Eight women used the OCP. Exclusion criteria included use of other forms of hormone treatment and a diagnosing of moderate or severe dry eye. Information about menstrual cycle length and current status was collected.Subjects completed the DOSS, which comprises oftwo questions rating intensity of discomfort and dryness at a given moment. The items are adapted from the DEQ5 and rephrased. Subjects also completed existing dry eye questionnaires including the Ocular Comfort Index (OCI), Ocular Surface Disease Index (OSDI) and the 5-item Dry Eye Questionnaire (DEQ5). Spearman correlations were used to evaluate association between DOSS and other questionnaires. Mann-Whitney U test wasused to compare scores between subjects using the OCP and non-OCP users and between phases of the menstrual cycle.
Results: DOSS scores were significantly correlated with OCI (ρ=0.53, p=0.002), OSDI (ρ=0.52, p=0.002) and DEQ5 (ρ=0.67, p<0.001) scores. Symptoms scores were higher in women usingOCP, but this difference was only significant for theOSDI. Median, IQR in OCP group: 19.775 (15.10-24.45) and non-OCP group: 7.29 (0-10.41); p=0.04. Symptom scores at the cross-sectional visit did not differ significantly between luteal and follicular phases of the menstrual cycle.
Conclusions: The DOSS showed good correlation with existing questionnaires and could be used as a simple 2-item online tool to assess daily fluctuations in ocular discomfort and dryness symptoms over a complete menstrual cycle.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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