September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Clinical findings of Dry Eye Disease in a large Norwegian cohort based on osmolarity measurements
Author Affiliations & Notes
  • Sjur Reppe
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
  • Xiangjun Chen
    The Norwegian Dry Eye Clinic, Oslo, Norway
    Synslaser Surgery AS, Oslo, Norway
  • Sten Ræder
    The Norwegian Dry Eye Clinic, Oslo, Norway
    Synslaser Surgery AS, Oslo, Norway
  • Tor Paaske Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Department of Ophthalmology, Vestre Viken Hospital Trust, Drammen, Norway
  • Øygunn Aass Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
  • Aleksandar Stojanovic
    Synslaser Surgery AS, Oslo, Norway
    Eye Department, University Hospital North Norway, Tromsø, Norway
  • Neil S Lagali
    Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  • Darlene A Dartt
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Behzod Tashbayev
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Footnotes
    Commercial Relationships   Sjur Reppe, None; Xiangjun Chen, None; Sten Ræder, None; Tor Utheim, None; Øygunn Utheim, None; Aleksandar Stojanovic, None; Neil Lagali, None; Darlene Dartt, None; Behzod Tashbayev, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2859. doi:
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      Sjur Reppe, Xiangjun Chen, Sten Ræder, Tor Paaske Utheim, Øygunn Aass Utheim, Aleksandar Stojanovic, Neil S Lagali, Darlene A Dartt, Behzod Tashbayev; Clinical findings of Dry Eye Disease in a large Norwegian cohort based on osmolarity measurements. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2859.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To investigate clinical parameters in three osmolarity level subgroups in a large Norwegian cohort of dry eye disease (DED) patients.

Methods : This study was conducted on 470 patients diagnosed with DED of different etiologies. All patients received an extensive ophthalmological work-up. The cohort was divided into three groups based on tear osmolarity levels. Cut-off values for tear osmolarity (mOsm/L) were ≤300 (group 1); 301-320 (group 2), and ≥321 (group 3). Data are presented as mean with standard deviation. Pearson’s correlation was used for calculation. P values less than 0.05 were considered significant.

Results : Tear osmolarity levels ≤300 were seen in 17.2% of the patients (n=81), while 56.2% of patients (n=264) had tear osmolarity levels ranging from 301 to 320, and 26.6% of patients (n=125) had tear osmolarity levels ≥321. The tear film break-up times (TFBUT) of group 1 and group 2 were 5.43±4.42 and 4.59±3.64, respectively (p=0.081). The vital stainings of group 1 and group 2 were 1.12±1.8 and 1.24±1.60, respectively (p=0.738). The third group of patients, however, had significantly lower TFBUT values (3.99±3.67, p=0.008) and higher vital staining grade (1.95±4.79, p=0.041) compared to group 1, but not compared to group 2.

Conclusions : Patients with high tear osmolarity presented with more severe DED as reflected by lower TFBUT and higher vital staining grades. Thus, osmolarity measurements are useful in clinical practice.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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