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Kojiro Imai, Kazuhiko Mori, Yoko Ikeda, Morio Ueno, Haruna Yoshikawa, Yuko Maruyama, Yuji Yamamoto, Shigeru Kinoshita, Chie Sotozono; Retinal vascular caliber in normal-tension glaucoma patients according to visual field severity. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2968.
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© 2017 Association for Research in Vision and Ophthalmology.
Glaucoma is known to be a multifactorial disease comprised of intraocular pressure (IOP) and ocular hemodynamics. According to previous reports and our ARVO 2015 report, the retinal vascular caliber related with ocular hemodynamics is narrow in normal-tension glaucoma (NTG) patients. The purpose of this present study was to examine the retinal vascular caliber and ocular perfusion pressure in regard to the Anderson’s grade of glaucoma severity in NTG patients.
This observational study involved 45 untreated NTG patients (22 males and 23 females; mean age: 51.1±13.5 years) and 45 healthy controls (22 males and 23 females; mean age: 53.8±9.5 years), comparable in regard to age and sex who were seen at the Kyoto Prefectural University of Medicine Hospital and the Oike-Ikeda Eye Clinic, Kyoto, Japan. Both patients and control with all kinds of treatment history including internal remedy, except for dry-eye disease or allergic conjunctivitis, were excluded from the study. Based on the width data of the 6 largest venules and arterioles in a digital retinal image, we calculated the central retinal artery equivalent (CRAE), the central retinal vein equivalent (CRVE), and the arterioles-to-venules ratio (AVR) by IVAN software (kindly provided by the University of Wisconsin-Madison) using the Parr-Hubbard-Knudtson formula. Ocular perfusion pressure (OPP) was estimated using blood pressure and IOP measurements. NTG patients were categorized into three groups (mild, moderate, and severe stage) according to the Anderson’s grade. The non-paired t test and Dunnett’s test were used as statistics analyses.
CRAE, CRVE, AVR, and OPP were 128.0μm, 186.1μm, 0.69, and 44.2mmHg, respectively, in the NTG group, and 135.4μm, 198.4μm, 0.69, and 50.0mmHg, respectively, in the control group. CRAE, CRVE, and OPP were significantly lower in the NTG group than in the control group (p<0.01, respectively). The NTG group consisted of 13 mild, 18 moderate, and 14 severe stage patients. CRAE and CRVE were significantly narrower in the moderate and severe stage, and OPP was significantly lower in the mild stage, compared with the control group (p<0.05, respectively).
Ocular hemodynamics may vary among NTG patients from the aspect of the classification of severity.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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