September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Baseline retrobulbar blood flow velocities correlate more strongly with changes in retinal capillary density over 4 years in open angle glaucoma patients with diabetes mellitus
Author Affiliations & Notes
  • Casey Seizys
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Amelia Huang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Casey Seizys, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Nicholas Moore, None; Amelia Huang, None; Darrell WuDunn, Aerie Pharmaceuticals (F), Allergan (F), InnFocus (F), Mati Therapeutics (F); George Eckert, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY, and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2972. doi:
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      Casey Seizys, Alon Harris, Alice Chandra Verticchio Vercellin, Nicholas Moore, Amelia Huang, Darrell WuDunn, George Eckert, Brent A Siesky; Baseline retrobulbar blood flow velocities correlate more strongly with changes in retinal capillary density over 4 years in open angle glaucoma patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2972.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between baseline retrobulbar blood flow velocities and longitudinal changes in capillary blood flow in open angle glaucoma (OAG) patients with and without diabetes mellitus (DM)

Methods : 78 patients with OAG (16 with DM, 62 without DM) were assessed for peak systolic (PSV) and end diastolic (EDV) velocities in the nasal and temporal posterior ciliary arteries (NPCA, TPCA) by color Doppler imaging and for capillary blood flow by Heidelberg retinal flowmetry in superior and inferior temporal retinal quadrants at baseline and every 6 months for a 4-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients with DM, baseline NPCA and TPCA EDV were 2.42 (95% CI: 2.11, 2.79) and 2.32 (2.02, 2.67) in patients with DM, and 2.41 (2.23, 2.60) and 2.45 (2.27, 2.65) in patients without DM. In OAG patients with DM, baseline NPCA and TPCA EDV were positively and significantly correlated with changes in inferior retinal capillary density (% zero pixels) (NPCA EDV: r=0.63, p=0.0069; TPCA EDV: r=0.65, p=0.0052), leading to a significant difference compared to patients without DM (NPCA EDV: p=0.0344; TPCA EDV: p=0.0121). There were no significant findings for PSV or superior temporal quadrants of blood flow in the retina for either group.

Conclusions : In OAG patients with DM, baseline retrobulbar blood flow exhibited a significantly stronger relationship to changes in retinal capillary density after 4 years compared to non-diabetic glaucoma patients. This data suggests that the presence of DM may affect ocular blood vessels over time in OAG patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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