September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Systemic and local factors related to optic nerve head blood flow in patients with glaucoma
Author Affiliations & Notes
  • Yutaro Yamada
    Kanazawa University, Kanazawa, Japan
  • Tomomi Higashide
    Kanazawa University, Kanazawa, Japan
  • Satoshi Takeshima
    Kanazawa University, Kanazawa, Japan
  • Sachiko Udagawa
    Kanazawa University, Kanazawa, Japan
  • Kazuhisa Sugiyama
    Kanazawa University, Kanazawa, Japan
  • Footnotes
    Commercial Relationships   Yutaro Yamada, None; Tomomi Higashide, None; Satoshi Takeshima, None; Sachiko Udagawa, None; Kazuhisa Sugiyama, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2976. doi:
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      Yutaro Yamada, Tomomi Higashide, Satoshi Takeshima, Sachiko Udagawa, Kazuhisa Sugiyama; Systemic and local factors related to optic nerve head blood flow in patients with glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2976.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate systemic and local factors related to optic nerve head blood flow in patients with glaucoma.

Methods : We examined 163 eyes of 87 patients with glaucoma excluding the eyes with a history of glaucoma surgery and refractive surgery (82 eyes of 45 males; mean age, 62.2±11.9 years old). Optic nerve head (ONH) blood flow was measured with laser speckle flowgraphy (LSFG; Softcare, Japan). Here, we investigated the relationship between clinical parameters and ONH blood flow in all (MA), vessel (MV) and tissue (MT) areas using generalized linear mixed model with independent variables including age, sex, hypertension, diabetes mellitus, mean deviation (MD) in Humphrey visual field analyzer (24-2 SITA standard) (Carl Zeiss Meditec), best-corrected visual acuity, mean and range of the intraocular pressure (IOP) and ocular perfusion pressure (OPP) obtained from 2-day diurnal measurement, glaucoma medication score, axial length (AL) and lens status.

Results : Older age was significantly associated with lower ONH blood flow in MA, MV and MT (p=0.001, p=0.012, p=0.002, respectively). In patients with hypertension, ONH blood flow was significantly lower than patients without hypertension in MA, MV and MT (p<0.001, p<0.001, p<0.001, respectively). Worse MD was significantly associated with lower ONH blood flow in MA, MV and MT (p<0.001, p<0.001, p<0.001, respectively). Longer AL was significantly associated with lower ONH blood flow in MA, MV and MT (p<0.001, p<0.001, p<0.001, respectively). Higher mean OPP was significantly associated with higher ONH blood flow in MA, MV and MT (p=0.001, p=0.003, p=0.006, respectively). In diabetic patients, ONH blood flow was significantly lower than non-diabetic patients in MA and MT (p=0.011, p=0.021, respectively). In female patients, ONH blood flow was significantly higher than male patients only in MT (p=0.019).

Conclusions : Systemic and local factors such as age, sex, hypertension, diabetes mellitus, MD, AL and OPP were significantly associated with the ONH blood flow in patients with glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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