September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal changes in macular thickness correlate with changes in retrobulbar vascular resistance in open-angle glaucoma patients with diabetes mellitus
Author Affiliations & Notes
  • Thai Do
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, iRCCS Policlinico San Matteo, Pavia, Italy
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aditya Belamkar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Thai Do, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama Therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Nicholas Moore, None; Colin Ridenour, None; Aditya Belamkar, None; George Eckert, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2980. doi:
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      Thai Do, Alon Harris, Alice Chandra Verticchio Vercellin, Nicholas Moore, Colin Ridenour, Aditya Belamkar, George Eckert, Brent A Siesky; Longitudinal changes in macular thickness correlate with changes in retrobulbar vascular resistance in open-angle glaucoma patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2980.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To examine the relationship between changes in macular thickness and changes in retrobulbar blood flow in open-angle glaucoma (OAG) patients with and without diabetes mellitus (DM)

Methods : 78 patients with OAG (12 with DM, 66 without DM) were assessed for retrobulbar blood flow in the central retinal artery (CRA) and nasal posterior ciliary artery (NPCA) by color Doppler imaging, and for macular thickness by optical coherence tomography every six months for a four-year period. Pearson correlations were used to determine statistically significant (p<0.05) associations between measurements.

Results : In patients with DM, changes in CRA resistivity index (RI) were positively correlated with changes in macular thickness in the outer inferior segment (r=0.70, p=0.009), and changes in NPCA RI were positively correlated with changes in macular thickness in both the inner superior (r=0.72, p=0.007) and inner nasal segments (r=0.71, p=0.008). In OAG patients without DM, these correlations were weak and not significant (CRA RI and outer inferior segment: r=0.03, p=0.831; NPCA RI and inner superior: r=0.03, p=0.820, and inner nasal segments: r=-0.04, p=0.770); leading to a significant difference between groups (macular thickness: outer inferior p=0.018; inner superior p=0.015; inner nasal p=0.010).

Conclusions : In this group of OAG patients with DM, changes in macular thickness were more strongly correlated to changes in retrobulbar blood flow, compared to non-diabetic subjects. These data suggest that retrobulbar vascular resistance may play a larger role in changes to macular structure in patients with diabetes.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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