September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal changes in retrobulbar blood flow more strongly correlate with changes in optic nerve head structure in open-angle glaucoma patients with diabetes mellitus
Author Affiliations & Notes
  • Tyler Joseph Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Betul Kaskan
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Footnotes
    Commercial Relationships   Tyler Knight, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Brent Siesky, None; Nicholas Moore, None; Colin Ridenour, None; Betul Kaskan, None; George Eckert, None; Alice Chandra Verticchio Vercellin, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY, and American Diabetics Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2981. doi:
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      Tyler Joseph Knight, Alon Harris, Brent A Siesky, Nicholas Moore, Colin Ridenour, Betul Kaskan, George Eckert, Alice Chandra Verticchio Vercellin; Longitudinal changes in retrobulbar blood flow more strongly correlate with changes in optic nerve head structure in open-angle glaucoma patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2981.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between changes in retrobulbar blood flow velocities and changes in optic nerve head (ONH) structure in open-angle glaucoma (OAG) patients with and without diabetes mellitus (DM)

Methods : 79 patients with OAG (13 with DM, 66 without DM) were assessed for peak systolic velocity (PSV), end diastolic velocity (EDV), and resistivity index (RI) in the ophthalmic artery (OA), central retinal artery (CRA) and temporal posterior ciliary artery (TPCA) by color Doppler imaging and for ONH morphology and retinal nerve fiber layer (RNFL) thickness by Heidelberg retinal tomography 3 every six months for a four-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients with DM, changes in OA RI were positively correlated with changes in height variation contour (r=0.70, p=0.009). Changes in CRA RI were negatively correlated with changes in linear cup/disc ratio (r=-0.64, p=0.016). TPCA PSV and EDV negatively correlated with changes in mean RNFL thickness (PSV: r=-0.71, p=0.006, EDV: r=-0.64, p=0.017) and RNFL cross-sectional area (PSV: r=-0.72, p=0.004; EDV: r=-0.67, p=0.010). Additionally, TPCA EDV correlated positively with changes in cup area (r=0.63, p=0.018), and cup/disc area ratio (r=0.56, p=0.046), and negatively with rim area (r=-0.62, p=0.022), and rim volume (r=-0.66, p=0.012). In OAG patients without DM, these correlations were weak and non-significant (r=-0.11 to 0.12, all p>0.05); leading to a significant difference compared to patients without DM (p<0.05).

Conclusions : These results suggest that vascular factors may play a more prominent role in the structural progression of OAG in patients with DM, compared to those without DM.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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