September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Retinal blood flow more strongly correlates with systemic blood pressure and ocular perfusion pressure in open-angle glaucoma patients with diabetes mellitus
Author Affiliations & Notes
  • Katherine Hutchins
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Betul Kaskan
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Katherine Hutchins, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Nicholas Moore, None; Alice Chandra Verticchio Vercellin, None; Colin Ridenour, None; Betul Kaskan, None; George Eckert, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY, and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2982. doi:
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      Katherine Hutchins, Alon Harris, Nicholas Moore, Alice Chandra Verticchio Vercellin, Colin Ridenour, Betul Kaskan, George Eckert, Brent A Siesky; Retinal blood flow more strongly correlates with systemic blood pressure and ocular perfusion pressure in open-angle glaucoma patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2982.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between retinal volumetric blood flow and both systemic blood pressure (BP) and ocular perfusion pressure (OPP) in open-angle glaucoma (OAG) patients with and without diabetes mellitus (DM)

Methods : 120 patients with OAG (19 with DM, 91 without DM) were assessed for systemic BP and OPP and for volumetric blood flow in the retinal vessels by Doppler Fourier-domain optical coherence tomography. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients, the superior hemisphere blood flow (microliters/min) was 16.45 (standard error: 1.38) and 17.68 (0.58) in patients with and without DM, respectively. In OAG patients with DM, superior hemisphere blood flow was positively correlated with diastolic BP (DBP) (r=0.53, p=0.019), mean arterial pressure (MAP) (r=0.50, p=0.027), OPP (r=0.45, p=0.054), diastolic perfusion pressure (DPP) (r=0.49, p=0.032) and mean perfusion pressure (MPP) (r=0.47, p=0.041). In OAG patients without DM, these correlations were weak and non-significant (r=-0.12 to -0.02, all p>0.05); leading to a significant difference between groups (DBP: p=0.022; MAP: p=0.031; OPP: p=0.025; DPP: p=0.018; MPP: p=0.024).

Conclusions : In this group of OAG patients, systemic BP and OPP were positively correlated with volumetric blood flow in the superior retinal hemisphere only in diabetics. These results suggest that systemic blood and ocular perfusion pressures have a larger influence on retinal blood flow in diabetic patients compared to those without diabetes, possibly due to a lack of localized autoregulation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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