September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Retinal arterial vessel cross-sectional area more strongly correlates with structural parameters in open-angle glaucoma patients of African descent
Author Affiliations & Notes
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Amelia Huang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tyler Joseph Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Yara Catoira-Boyle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Brent Siesky, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Amelia Huang, None; Tyler Knight, None; Yara Catoira-Boyle, None; George Eckert, None; Darrell WuDunn, Aerie Pharmaceuticals (F), Allergan (F), InnFocus (F), Mati Therapeutics (F); Nicholas Moore, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY and NIH Grant 1R21EY022101-01A1
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2984. doi:
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      Brent A Siesky, Alon Harris, Alice Chandra Verticchio Vercellin, Amelia Huang, Tyler Joseph Knight, Yara Catoira-Boyle, George Eckert, Darrell WuDunn, Nicholas Moore; Retinal arterial vessel cross-sectional area more strongly correlates with structural parameters in open-angle glaucoma patients of African descent. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2984.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between retinal arterial vessel cross-sectional area and ocular structural parameters in open-angle glaucoma (OAG) patients of African (AD) and European descent (ED)

Methods : 122 patients with OAG (35 AD, 87 ED) were assessed for optic nerve head (ONH) morphology and retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) and for retinal arterial area by Fourier domain Doppler OCT. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : The mean arterial area (mm2) was 0.0316 (standard error, SE: 0.0010) and 0.0300 (SE: 0.0008) in patients of AD and ED, respectively. In OAG patients of AD, arterial area (mm2) was positively correlated with rim area (r=0.47, p=0.004), superior RNFL thickness (r=0.39, p=0.021), temporal RNFL thickness (r=0.40, p=0.017), average RNFL thickness (r=0.38, p=0.025), and negatively correlated with cup/disc area ratio (r=-0.38, p=0.025) and cup/disc vertical ratio (r=-0.44, p=0.008). In ED patients, correlations were weak and non-significant (r=-0.17 to 0.07; all p>0.05); leading to a significant difference between groups (rim area: p=0.027; superior RNFL thickness: p=0.009; temporal RNFL thickness: p=0.004, average RNFL thickness: p=0.018; cup/disc area ratio: p=0.045; cup/disc vertical ratio: p=0.010).

Conclusions : In OAG patients of AD, retinal arterial vessel cross-sectional area was positively correlated with ONH rim area and RNFL thickness, and negatively correlated with cup/disc ratio. These results suggest that retinal blood supply may have a greater influence on structural markers of OAG disease in patients of AD compared to ED patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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