September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Lower baseline ophthalmic artery blood flow velocities predict glaucomatous functional progression differently according to gender
Author Affiliations & Notes
  • Amelia Huang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tyler Joseph Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Betul Kaskan
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Christian Jonescu-Cuypers
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Amelia Huang, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama Therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Nicholas Moore, None; Tyler Knight, None; Betul Kaskan, None; Christian Jonescu-Cuypers, None; George Eckert, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2985. doi:
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      Amelia Huang, Alon Harris, Alice Chandra Verticchio Vercellin, Nicholas Moore, Tyler Joseph Knight, Betul Kaskan, Christian Jonescu-Cuypers, George Eckert, Brent A Siesky; Lower baseline ophthalmic artery blood flow velocities predict glaucomatous functional progression differently according to gender. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2985.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To examine retrobulbar blood flow parameters as they relate to functional progression in males and females with open-angle glaucoma (OAG) over a five-year period

Methods : 111 OAG patients (mean age 65 ± 10.9 years; 43 male, 68 female) were assessed for retrobulbar blood flow in the ophthalmic artery (OA), which was measured by color Doppler imaging at baseline and every six months for a five-year period. 73 patients (mean age 70 ± 10.9 years; 31 male, 42 female) were assessed at five-year follow-up. Visual field analysis was performed with Humphrey 24-2 and functional disease progression was defined as two consecutive visits with mean deviation decrease ≥2 and/or Advanced Glaucoma Intervention Study score increase ≥2 compared to baseline. Mixed-model ANCOVA was used to test for significant changes from baseline to five-year follow-up. Time to functional progression was analyzed using Cox proportional hazard models. Interactions were tested to determine if the effects of the factors on progression time differed by sex.

Results : OA end diastolic velocity (EDV) in males decreased from 5.7 (95% CI: 5.0, 6.6) at baseline to 4.6 (3.8, 5.5) at five years, mean change -1.4 (-2.7, -0.4; p=0.006). OA EDV in females decreased from 5.5 (4.9, 6.1) at baseline to 3.4 (3.1, 4.0) at five years, mean change -3.2 (-4.3, -2.2; p<0.001). Lower baseline OA EDV was associated with shorter time to functional progression in male (p=0.003), but not in female patients, leading to a significant difference between groups (p=0.040).

Conclusions : In this study, lower baseline retrobulbar blood flow was more predictive of functional vision loss after five years in males compared to females. These data suggest that blood flow may have a greater influence on time to disease progression based upon gender in certain patients with OAG.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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