September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield
Author Affiliations & Notes
  • Kazuyuki Hirooka
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Takeru Shimazaki
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Yuuki Nakano
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Eri Nitta
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Kaori Ukegawa
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Shino Sato
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Akitaka Tsujikawa
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Kagawa, Japan
  • Footnotes
    Commercial Relationships   Kazuyuki Hirooka, None; Takeru Shimazaki, None; Yuuki Nakano, None; Eri Nitta, None; Kaori Ukegawa, None; Shino Sato, None; Akitaka Tsujikawa, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2988. doi:
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      Kazuyuki Hirooka, Takeru Shimazaki, Yuuki Nakano, Eri Nitta, Kaori Ukegawa, Shino Sato, Akitaka Tsujikawa; Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2988.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between visual field defects in the upper and lower hemifields and the corresponding oxygen saturation of the retinal vessels in patients with glaucoma.

Methods : This study enrolled 44 glaucoma patients who had more than a 10 dB difference between the upper and lower total deviation (TD). Retinal vessel oxygen saturation was measured with a non-invasive spectrophotometric retinal oximeter. The hemifields in one eye of each patient were divided into worse (worse TD) and better (better TD) hemifield areas. We also examined an additional 40 glaucoma patients who had less than a 5 dB difference between upper and lower TD. Statistical analysis was performed using a Student’s t-test.

Results : Mean venous saturation of oxygen (SaO2) was higher in the worse (59.0 ± 8.0%) versus the better (55.4 ± 7.2%) hemifield (P < 0.01). The mean arteriovenous difference in the SaO2 was lower in the worse (44.4 ± 9.0%) versus the better (48.6 ± 11.4%) hemifield (P = 0.02). However, no statistical difference was found for the retinal SaO2 in the venous vessels or for the arteriovenous difference between the worse and better hemifield in patients with less than a 5 dB difference in the upper and lower hemifield TD.

Conclusions : Advanced glaucomatous visual field defects are associated with increased SaO2 in the venous vessels and a decreased arteriovenous difference in the SaO2. Data suggest that there is a reduced retinal oxygen consumption in eyes with glaucomatous damage due to retinal ganglion cell loss.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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