September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Glaucoma
Author Affiliations & Notes
  • Naoki Kiyota
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Yukihiro Shiga
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Marika Sato
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Shigeto Maekwa
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Kazuko Omodaka
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Kazuichi Maruyama
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Hidetoshi Takahashi
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Hiroshi Kunikata
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Toru Nakazawa
    Ophthalmology, Tohoku university school of medicine, Sendai-shi, Miyagi, Japan
  • Footnotes
    Commercial Relationships   Naoki Kiyota, None; Yukihiro Shiga, None; Marika Sato, None; Shigeto Maekwa, None; Kazuko Omodaka, None; Kazuichi Maruyama, None; Hidetoshi Takahashi, None; Hiroshi Kunikata, None; Toru Nakazawa, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2992. doi:
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      Naoki Kiyota, Yukihiro Shiga, Marika Sato, Shigeto Maekwa, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi, Hiroshi Kunikata, Toru Nakazawa; The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2992.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : It has been suggested that dysfunctional autoregulation of optic nerve head blood flow is associated with the pathology of glaucoma. Thus, methods to evaluate autoregulatory capacity are needed. Previously, we described a laser speckle flowgraphy-based method to quantify autoregulatory capacity during oxygen inhalation in normal subjects (Shiga Y et al. 2014). Here, we evaluate this technique in open-angle glaucoma (OAG) patients.

Methods : This study comprised 12 eyes of 12 OAG patients (age: 54.4 ± 12.7 years, mean deviation: -3.4 ± 4.0 dB) and 12 age-matched eyes of 12 normal subjects (age: 55.2 ± 8.1 years). The testing protocol had three stages: baseline, hyperoxia (12 min of pure oxygen at 6L/min), and recovery (4 min of room air). Before and after oxygen inhalation, we evaluated optic nerve head blood flow according to the mean blur rate (MBR), an LSFG-derived variable. We measured blood pressure (BP), heart rate (HR), and peripheral capillary oxygen saturation (SpO2) every 5 min.
Ocular perfusion pressure (OPP) was calculated using baseline IOP. We compared the variables at each measured time point in both groups.

Results : No significant changes were seen in BP, HR, or OPP (P = 0.39-0.98) during the testing despite a significant increase in SpO2 during hyperoxia in both groups (P < 0.0001). MBR was significantly higher during hyperoxia in the OAG patients than in the normal subjects (90.7 ± 8.8% vs. 85.0 ± 4.6%, respectively, P = 0.04; baseline = 100% in both).

Conclusions : The response to hyperoxia was significantly lower in the OAG patients. This result may indicate that autoregulation becomes dysfunctional in glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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