September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Evaluation of retinal blood flow before and after topical tafluprost treatment in glaucoma patients using adaptive optics scanning laser ophthalmoscopy
Author Affiliations & Notes
  • Yuto Iida
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Tadamichi Akagi
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Hanako Ikeda
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Satoshi Morooka
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Kenji Suda
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Tomoko Hasegawa
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Hiroshi Yamada
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Munemitsu Yoshikawa
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Akihito Uji
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Nagahisa Yoshimura
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Kyoto Pref., Japan
  • Footnotes
    Commercial Relationships   Yuto Iida, None; Tadamichi Akagi, None; Hideo Nakanishi, None; Hanako Ikeda, None; Satoshi Morooka, None; Kenji Suda, None; Tomoko Hasegawa, None; Hiroshi Yamada, None; Munemitsu Yoshikawa, None; Akihito Uji, None; Nagahisa Yoshimura, Canon (F), Canon (C), Canon (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2995. doi:
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      Yuto Iida, Tadamichi Akagi, Hideo Nakanishi, Hanako Ikeda, Satoshi Morooka, Kenji Suda, Tomoko Hasegawa, Hiroshi Yamada, Munemitsu Yoshikawa, Akihito Uji, Nagahisa Yoshimura; Evaluation of retinal blood flow before and after topical tafluprost treatment in glaucoma patients using adaptive optics scanning laser ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2995.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Adaptive optics scanning laser ophthalmoscopy (AO-SLO) enables clear visualization of retinal microstructures and detailed analysis of the microcirculatory status non-invasively. Topical tafluprost was previously reported to increase ocular blood flow in animal models of glaucoma, but it remains unclear whether tafluprost increases absolute ocular blood flow in human glaucomatous eyes. In this study, we evaluated the effects of topical tafluprost on the absolute retinal blood flow in glaucoma patients using AO-SLO.

Methods : This prospective observational study included 7 eyes of 7 patients with untreated primary open-angle glaucoma. The participants underwent comprehensive ophthalmic examinations including standard automated perimetry (SAP) at the inclusion. AO-SLO and intraocular pressure (IOP) and blood pressure measurements were performed at baseline and 1 and 4 weeks after the topical tafluprost induction. The AO-SLO videos were obtained from parafoveal areas to cover the innermost capillary ring. To assess the retinal blood flow, we used aggregated erythrocyte velocity (AEV), which was measured at the innermost vessel of the capillary ring and calculated using spatiotemporal images generated from AO-SLO videos. The identical capillary vessel selected at the baseline was used to measure AEV during follow-up examinations in each patient.

Results : At the baseline, the mean age was 53.0±8.9 years and the average mean deviation (MD) value in SAP was -6.90±4.89 dB. The mean axial length was 25.34±1.56 mm. After topical tafluprost induction, the AEV increased significantly (baseline: 1.08±0.15 mm/sec, 1 week: 1.22±0.14 mm/sec, p=0.003, 4 weeks: 1.29±0.20 mm/sec, p=0.001), and the IOP decreased significantly (baseline: 17.4±2.1 mmHg, 1 week: 13.6±1.1 mmHg, p=0.003, 4 weeks: 14.3±2.1 mmHg, p=0.004). The blood pressure was not different between the baseline and after the treatments.

Conclusions : Using AO-SLO, we successfully evaluated the retinal blood flow in patients with glaucoma. Topical tafluprost treatment significantly increased AEV in addition to significantly reducing IOP.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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