September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Efficacy of 4% Hydroquinone in Japanese Glaucoma Patients with Topical Prostaglandin Analogue-induced Eyelid Pigmentation: A Randomized, Evaluators-Blinded, Left-Right Comparison Study
Author Affiliations & Notes
  • Koichi Ono
    Department of Ophthalmology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-ku, Tokyo, Japan
  • Rie Ueki
    Department of Dermatology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-Ku, Japan
  • Tairo Kimura
    Department of Ophthalmology, Ueno Eye Clinic, Taito-ku, Tokyo, Japan
  • Kayoko Akimoto
    Department of Dermatology, Skin Care Ueno Clinic, Taito-ku, Tokyo, Japan
  • Reiko Umeya
    Department of Ophthalmology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-ku, Tokyo, Japan
  • Ken Akashi
    Department of Dermatology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-Ku, Japan
  • Sakiko Ohgiya
    Department of Dermatology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-Ku, Japan
  • Makoto Kawashima
    Department of Dermatology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Koichi Ono, None; Rie Ueki, None; Tairo Kimura, None; Kayoko Akimoto, None; Reiko Umeya, None; Ken Akashi, None; Sakiko Ohgiya, None; Makoto Kawashima, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3027. doi:
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      Koichi Ono, Rie Ueki, Tairo Kimura, Kayoko Akimoto, Reiko Umeya, Ken Akashi, Sakiko Ohgiya, Makoto Kawashima; Efficacy of 4% Hydroquinone in Japanese Glaucoma Patients with Topical Prostaglandin Analogue-induced Eyelid Pigmentation: A Randomized, Evaluators-Blinded, Left-Right Comparison Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3027.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To examine the efficacy of 4% hydroquinone cream for improving eyelid pigmentation induced by topical prostaglandin analogues.

Methods : A randomized, multicenter, evaluators (providers and statisticians)-blinded, intra-patient comparison (left vs. right eye) was performed. Twenty-two Japanese glaucoma patients with similar pigmentation of both lower eyelids due to topical prostaglandin analogues were recruited at two sites. The subjects applied 4% hydroquinone cream to one eyelid twice a day for 12 weeks after washing their face carefully. The treated eye was selected by opening an opaque sealed envelope that was prepared by an independent third party. The providers and the statistical expert were blinded regarding treatment information until code opening. Bilateral eyelid skin color was measured using the Skin Tone Color Scales (Hadatone Checker, Daiichi Sankyo Healthcare) by well-trained dermatologists at baseline and after 4 weeks, 8 weeks, and 12 weeks of treatment. Changes in the color of both lower eyelids from baseline were analyzed by repeated measures ANOVA. Written informed consent was obtained from all participants. This study was approved by the institutal review board of Juntendo Tokyo-Koto Geriatric Medical Center, and was registered with UMIN (Trial number: UMIN 000011524). Our study adhered to the Declaration of Helsinki.

Results : Nineteen subjects (14 women/5 men)completed all examinations and were analyzed [mean age (+/-SD): 72.6+/-11.1 years]. The mean change of eyelid color from baseline was respectively 0.237, 0.487, and 0.579 after 1 week, 2 weeks and 3 weeks for the treated eyelids, while it was respectively 0.224, 0.263, and 0.342 for the untreated eyelids. A significant difference of the change was noted between the treated and untreated eyelids at 3 weeks.

Conclusions : Application of 4% hydroquinone cream significantly reduced topical prostaglandin-induced eyelid pigmentation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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