September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
A Randomized Trial of AmblyzTM Liquid Crystal Occlusion Glasses vs Traditional Patching for Treatment of Moderate Unilateral Amblyopia in Children: 6-Month Outcome
Author Affiliations & Notes
  • Paxton Ott
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Daniel Neely
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Jay Galli
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Tina Damarjian
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Joshua Schliesser
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Heather Smith
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Kathryn Haider
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Gavin Roberts
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Derek Sprunger
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • David Plager
    Vision Sciences, Indiana University School of Medicine, Clayton, Indiana, United States
  • Jingyun Wang
    Pennsylvania College of Optometry, Salus University , Elkins Park, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Paxton Ott, None; Daniel Neely, None; Jay Galli, None; Tina Damarjian, None; Joshua Schliesser, None; Heather Smith, None; Kathryn Haider, None; Gavin Roberts, None; Derek Sprunger, None; David Plager, None; Jingyun Wang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3079. doi:
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      Paxton Ott, Daniel Neely, Jay Galli, Tina Damarjian, Joshua Schliesser, Heather Smith, Kathryn Haider, Gavin Roberts, Derek Sprunger, David Plager, Jingyun Wang; A Randomized Trial of AmblyzTM Liquid Crystal Occlusion Glasses vs Traditional Patching for Treatment of Moderate Unilateral Amblyopia in Children: 6-Month Outcome. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3079.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We have previously reported the promising 3-month outcome on our clinical trial to comparing Amblyz intermittent occlusion glasses with traditional adhesive patching for treatment of moderate unilateral amblyopia. We now report our 6-month outcomes.

Methods : Children from 3 to 8 years of age with previously untreated, moderate, unilateral amblyopia (visual acuity of 20/40 to 20/80 in the amblyopic eye) were enrolled. All subjects had worn optimal refractive correction (if needed) for at least 12 weeks and their amblyopia was associated with strabismus, anisometropia, or both. Subjects were randomized into one of two treatment groups: a 4-hour daily Amblyz™ occlusion glasses group with liquid crystal shutter set at 30-second opaque/transparent intervals (Amblyz Group), or the 2-hour adhesive patching control group (Patching Group). For each patient, visual acuity was measured with ATS-HOTV methods for enrollment and follow-up exam.

Results : Eighteen children were available for 6-month treatment outcome visits (Amblyz Group N=9; Patching Group N=9). Both groups were significantly improved compared with the baseline at enrollment. Visual acuity in the amblyopic eye improved an average of 0.11±0.13 logMAR in the Amblyz Group and 0.20±0.18 logMAR in the Patching Group. Although slightly lower in the Amblyz Group, this difference between two groups was not statistically significant (P=0.24). Improvement from 3-month to 6-month was not statistically significant for both groups.

Conclusions :
Treatment of moderate amblyopia with Amblyz™ glasses was equally effective compared to treatment with traditional adhesive patches. Both groups showed the most amount of improvement during the first 3 months of treatment. Amblyz liquid crystal occlusion glasses are a promising alternative treatment for moderate amblyopia in children 3 to 8 years of age.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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