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Noriyasu Hashida, Shizuka Koh, Takeshi Soma, Yoshinori Oie, Naoyuki Maeda, Kohji Nishida; Diagnostic evaluation of RTVue-100 fourier-domain corneal anterior module OCT system in uveitic eyes of various etiologies. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3287.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the morphologic appearance of keratic precipitate (KPs) with RTVue-100 fourier-domain corneal anterior module optical coherence tomography (OCT) system (RTVue) (optovue, USA) for the diagnosis of uveitic eyes of various etiologies.
Ninety eyes of 90 patients with different types of uveitis were examined to investigate the morphologic appearance of KPs. The study included herpetic iridocyclitis/endotheliitis in 36 eyes, ocular sarcoidosis in 31 eyes, and masquerade syndrome with primary vitreoretinal lymphoma (PVRL) in 23, respectively. RTVue was used to analyze the differences in types of KPs among various uveitic groups. In the herpetic iridocyclitis/endotheliitis cases, polymerase chain reaction (PCR) was used for the detection of the causative virus from the aqueous humor.
KPs were observed seven eyes in ocular sarcoidosis group, 8 eyes in PVRL group. In the herpetic iridocyclitis/endotheliitis group, all cases showed KPs (13 cases were positive for herpes simplex virus, 14 cases for varicella zoster virus, and 9 cases for cytomegalovirus). In RTVue examination, intensity of KPs demonstrated various patterns. Morphologic features of KPs also showed various patterns such as globular, dome-shaped, saw-edged, rectangle-shaped appearance protruded from the retrocornea. Especially, dome-shaped and relatively big KPs were observed in ocular sarcoidosis cases. In contrast, relatively high intensity and dense KPs were observed in PVRL cases. In herpetic iridocyclitis cases, KPs were diffusely scattered over the corneal endothelium, but, through the course of antiviral treatment, they aggregated each other and deposited dispersedly.
RTVue images in various type of uveitic eye diseases showed characteristic and specific morphological patterns. RTVue examination is non-invasive and repeatable methods for diagnosis of uveitis by evaluating the KPs morphologies and treatment effectiveness.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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