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Eliott Kim, Elliot Crane, Jason S. Kim, May Shum, David S Chu; Literature Review: Comorbidities and Complications with Intermediate Uveitis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3311.
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© ARVO (1962-2015); The Authors (2016-present)
To report the prevalence of systemic diseases and ocular complications in subjects with intermediate uveitis in the literature.
PubMed was searched for “("intermediate uveitis" OR "pars planitis") AND ("systemic disease" OR complication)” in December 2015, resulting in 90 articles. After screening the abstracts, 78 articles were not related or did not include all subjects with intermediate uveitis from their defined institution.
12 articles met inclusion criteria, each with 8-438 subjects with intermediate uveitis. 28.9%-50.9% were male and 46.6%-100% had bilateral uveitis. 73.2%-94.4% of intermediate uveitis was idiopathic. Intermediate uveitis was associated with tuberculosis 1.1%-6.55% of the time, sarcoidosis 2.5%-10.3% of the time, Behcet’s disease 2.05%-18.6% of the time, Herpetic uveitis 0.46-1.1% of the time, Lyme disease 1.4% of the time, multiple sclerosis 5.56%-10.50% of the time, Fuch’s uveitis syndrome 7.3% of the time, and juvenile idiopathic arthritis 0.46% of the time. Subjects with intermediate uveitis also developed cystoid macular edema 59%-60% of the time, cataract 33.3% of the time, glaucoma 21.8% of the time, optic disk involvement 15-21.8% of the time, posterior synechiae 10-12.8% of the time, epiretinal membrane 17.3% of the time, peripheral neovascularization 9% of the time, retinal breaks 3.8% of the time, and retinal detachment 2.6% of the time.
Intermediate uveitis tends to affect females more than males and tends to affect both eyes. Although it is usually idiopathic, it may be associated with a variety of systemic and infections conditions.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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