September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Measurement of Iris Lesion Volume with Anterior Segment Swept-Source Optical Coherence Tomography
Author Affiliations & Notes
  • Laura Vickers
    Ophthalmology, Doheny Eye Institute-UCLA, Pasadena, California, United States
  • Handan AKIL
    Ophthalmology, Doheny Eye Institute-UCLA, Pasadena, California, United States
    Doheny Image Reading Center, Los Angeles, California, United States
  • Elmira Baghdasaryan
    Ophthalmology, Doheny Eye Institute-UCLA, Pasadena, California, United States
    Doheny Image Reading Center, Los Angeles, California, United States
  • Olivia L Lee
    Ophthalmology, Doheny Eye Institute-UCLA, Pasadena, California, United States
    Doheny Image Reading Center, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Laura Vickers, None; Handan AKIL, None; Elmira Baghdasaryan, None; Olivia Lee, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3386. doi:
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    • Get Citation

      Laura Vickers, Handan AKIL, Elmira Baghdasaryan, Olivia L Lee; Measurement of Iris Lesion Volume with Anterior Segment Swept-Source Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3386.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To calculate the volume of iris lesions using anterior segment swept-source optical coherence tomography (OCT) to enhance the clinical assessment of lesions, with comparison to the gold standard ultrasound biomicroscopy (UBM).

Methods : Two eyes of two patients with iris lesions underwent imaging with anterior segment swept-source OCT (Casia SS-1000, Tomey, Nagoya, Japan) as well as ultrasound biomicroscopy (Ellex Eyecubed 40 MHz UBM, Ellex medical Pty. Adelaide, Australia). Image processing software ImageJ (U. S. National Institutes of Health, Bethesda, Maryland, USA) was used to calculate the iris lesion volume from the 3-dimensional (3D) gonioscopic reconstruction of the OCT images. Lesion volume as calculated from the OCT was compared to lesion height as measured by UBM.

Results : One iris lesion, a clinically diagnosed iris melanoma, measured 5.7 mm in greatest circumference and 5.5 µL volume. The second iris lesion, clinically diagnosed as a large cyst, involved both the ciliary body and iris, measuring 15.4 mm greatest circumference and 76.0 µL volume.

Conclusions : Anterior segment OCT with 3D gonioscopic reconstruction can be used to calculate the volume of iris lesions. This may be used for clinical monitoring of lesions including change in size over time. Future studies of a greater number of eyes over time will compare sensitivity of OCT versus UBM for detection of change in size of iris lesions.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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