September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The prognostic effect of peripheral non-perfusion on macular thickness and visual acuity in diabetic and venous occlusive retinopathies.
Author Affiliations & Notes
  • Razek Georges Coussa
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Cyril Archambault
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Mikel Mikhail
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Fares Antaki
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • David E Lederer
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships   Razek Georges Coussa, None; Cyril Archambault, None; Mikel Mikhail, None; Fares Antaki, None; David Lederer, Alcon Inc (C), Bayer Inc (C), Novartis Pharmaceuticals Inc. (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3402. doi:
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      Razek Georges Coussa, Cyril Archambault, Mikel Mikhail, Fares Antaki, David E Lederer; The prognostic effect of peripheral non-perfusion on macular thickness and visual acuity in diabetic and venous occlusive retinopathies.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3402.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To study the prognostic effect of peripheral retinal non-perfusion on macular thickness and visual acuity in diabetic and venous occlusive retinopathies.

Methods : 156 and 53 treatment naive eyes with diabetic (88% NPDR and 12% PDR) and venous occlusion (40% BRVO, 13% HRVO and 47% CRVO) retinopathies, respectively, were randomly selected from our practice between August 2008 and August 2014. Wide-field retinal funds photos and fluorescein angiography (FA) were obtained on all patients using the Optos 200 Tx system (Optos plc, Scotland, UK). The peripheral perfusion index (PI), which was defined as the area beyond 45 degrees, was calculated using ImageJ 1.43 software. Student t-tests and regression analyses were used to analyze the data.

Results : 47% of DR and 55% of RVO subjects showed significant linear correlation between % peripheral and central non-perfusion. Ignoring peripheral non-perfusion misses ≈50% of total non-perfusion. In NPDR, macular thickness and central non-perfusion statistically affected VA. The average extent of peripheral non-perfusion was 2.2x fold larger in RVO compared to DR (8.8% RVO vs. 3.9% DR). In RVO, the effect of peripheral non-perfusion on VA was 2x folds significantly larger than that of macular thickness.

Conclusions : Peripheral non-perfusion sheds potential prognostic insights in vaso-occlusive retinopathies. In the future, peripheral non-perfusion could potentially be included in vaso-occlusive retinopathies' disease staging in order to enhance guided treatment options.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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