September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
CORRELATION IN RETINAL NERVE FIBER LAYER THICKNESS IN UVEITIS AND HEALTHY EYES USING SCANNING LASER POLARIMETRY AND
OPTICAL COHERENCE TOMOGRAPHY
Author Affiliations & Notes
  • David Bellocq
    Ophthalmology, Croix Rousse University Hospital, LYON, France
  • Laurent Kodjikian
    Ophthalmology, Croix Rousse University Hospital, LYON, France
  • Philippe Denis
    Ophthalmology, Croix Rousse University Hospital, LYON, France
  • Footnotes
    Commercial Relationships   David Bellocq, None; Laurent Kodjikian, None; Philippe Denis, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3412. doi:
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      David Bellocq, Laurent Kodjikian, Philippe Denis; CORRELATION IN RETINAL NERVE FIBER LAYER THICKNESS IN UVEITIS AND HEALTHY EYES USING SCANNING LASER POLARIMETRY AND
      OPTICAL COHERENCE TOMOGRAPHY
      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):3412.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured by spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP) in uveitis eyes compared to healthy eyes

Methods : Descriptive, observational, prospective, consecutive, controlled, monocenter case series have been conducted from May to October 2015. Clinical characterizes, best-corrected visual acuity (BCVA), intra-ocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness measurement with spectral domain optical coherence tomography (SD OCT) and scanning laser polarimetry (SLP) using GDx variable corneal compensation (GDx VCC) have been performed for each patient. An evaluation of anterior chamber inflammation with laser flare cell meter has also been made. Correlation between SD-OCT and GDx VCC RNFL measurement was evaluated with linear regression analysis.

Results : Fifty-four patients have been included and divided in two groups: 50 healthy eyes of 29 patients and 42 uveitic eyes of 25 patients. The mean RNFL thickness was 98.08 (standard deviation 8.42) and 113.21 (20.53) microns in the healthy group and the uveitic group by SD-OCT (p<0,001) and 56.43 (5.24) and 58.77 (6.67) microns by GDx VCC (p=0.078) respectively. The total average RNFL thickness correlated highly when measured using SD-OCT and GDX (r=0.48, p<0.001) in healthy eyes but not in uveitic eyes (r=0.2, p=0.19).

Conclusions : RNFL thickness was significantly increased using SD-OCT in active uveitis compared to GDx VCC. RNFL thickness measurement seems not to be correlated between these two techniques in active uveitic eyes. Discrepancy between the results obtained with SD-OCT and GDx VCC may suggest that accurate measurement of RNFL may associate the use of the two techniques for these patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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