September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Cognitive Decline is Associated with Increased Visual Field Variability in Glaucoma
Author Affiliations & Notes
  • Maria Valeria C P Silva
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
    Department of Ophthalmology and Otorhinolaryngology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Alberto Diniz-Filho
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
    Department of Ophthalmology and Otorhinolaryngology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Sebastiao Cronemberger
    Department of Ophthalmology and Otorhinolaryngology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Felipe A Medeiros
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Maria Valeria Silva, None; Alberto Diniz-Filho, None; Sebastiao Cronemberger, None; Felipe Medeiros, Alcon (F), Alcon (R), Allergan (C), Allergan (F), Allergan (R), Bausch & Lomb (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Heidelberg Engineering (F), Merck (F), National Eye Institute (F), Novartis (C), Reichert (F), Reichert (R), Sensimed (F), Topcon (F)
  • Footnotes
    Support  NIH grant EY021818 and NIH core grant P30EY022589.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Maria Valeria C P Silva, Alberto Diniz-Filho, Sebastiao Cronemberger, Felipe A Medeiros; Cognitive Decline is Associated with Increased Visual Field Variability in Glaucoma. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the relationship between cognitive decline and variability on visual fields in patients with glaucoma and suspected of having the disease followed over time.

Methods : The study involved 189 eyes of 105 patients followed for an average period of 2.6 ± 0.7 years. Eighty-three (79%) patients had a diagnosis of glaucoma and 22 (21%) were considered glaucoma suspects. All patients had Montreal Cognitive Assessment (MoCA) questionnaires and standard automated perimetry (SAP) tests during follow-up. Change in cognitive scores was assessed by calculating the difference between MoCA scores at the last follow-up visit from those at baseline. Visual field variability was estimated through the residuals of SAP mean deviation (MD) from linear regression over time. Generalized estimating equations models were used to investigate the relationship between variability on visual fields and cognitive decline, taking into account the correlation between fellow eyes, and also adjusting for potentially confounding factors.

Results : There was a significant correlation between change in MoCA scores and variability in SAP MD. A 5-unit decline in MoCA score was associated with an increase of 0.15 dB in variability of SAP MD during the follow-up period (P=0.002). For comparison, a 10 dB lower SAP MD was associated with an increase of 0.10 dB in variability during the follow-up period (P<0.001). In a multivariable model adjusting for baseline MoCA score, SAP MD, age, gender, race, and number of visits, each 5-unit decline in MoCA score was associated with a change of 0.10 dB in SAP MD during the follow-up period (P=0.023).

Conclusions : Cognitive decline was associated with increased visual field variability during follow-up in patients with glaucoma and suspects.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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