September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Does dry eye severity correlate with somatosensory function in the V1 distribution of the trigeminal nerve?
Author Affiliations & Notes
  • Anat Galor
    Ophthalmology, Miami VAMC, Miami, Florida, United States
    Ophthalmology, Bascom Palmer, Miami, Florida, United States
  • Ben Seiden
    Ophthalmology, Miami VAMC, Miami, Florida, United States
  • Katherine T McManus
    Ophthalmology, Miami VAMC, Miami, Florida, United States
  • Jasmine J Park
    Ophthalmology, Miami VAMC, Miami, Florida, United States
  • Roy C Levitt
    Anesthesiology, Miami VAMC, Miami, Florida, United States
  • Constantine D Sarantopoulos
    Anesthesiology, Miami VAMC, Miami, Florida, United States
  • Elizabeth Felix
    Research Services, Miami VAMC, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Anat Galor, None; Ben Seiden, None; Katherine McManus, None; Jasmine Park, None; Roy Levitt, None; Constantine Sarantopoulos, None; Elizabeth Felix, None
  • Footnotes
    Support  Supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development’s Career Development Award CDA-2-024-10S (Dr. Galor), NIH Center Core Grant P30EY014801 and Research to Prevent Blindness Unrestricted Grant.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Anat Galor, Ben Seiden, Katherine T McManus, Jasmine J Park, Roy C Levitt, Constantine D Sarantopoulos, Elizabeth Felix; Does dry eye severity correlate with somatosensory function in the V1 distribution of the trigeminal nerve?. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate associations between ocular signs and symptoms of dry eye (DE) and somatosensory function in the V1 distribution of the trigeminal nerve.

Methods : Cross-sectional study of individuals seen in the Miami Veterans Affairs eye clinic with a spectrum of dry eye symptoms and signs (none to severe). The evaluation consisted of questionnaires regarding DE symptoms (dry eye questionnaire 5, DEQ5; ocular surface disease index, OSDI) and ocular pain (numerical rating scale, NRS; short-form McGill Pain Questionnaire, sf-MPQ), a comprehensive ocular surface examination, and quantitative sensory testing (QST) performed on the forehead. QST metrics included threshold measurements of thermal and vibratory sensations, temporal summation of pain, painful aftersensations, and conditioned pain modulation. The main outcome measures were correlations between QST metrics and signs and symptoms of DE.

Results : 100 subjects participated in the study (mean age of 60 ± 10 years, 88% men). Greater severity of DE symptoms and ocular pain were associated with enhanced aftersensations to noxious cold stimulation (a potential indicator of central sensitization of ascending nociceptive information), and more robust descending inhibition of pain (suggestive of an intact descending inhibitory pathway). Conversely, more unhealthy tear film abnormalities were associated with findings of reduced or absent aftersensations to noxious hot stimulation (corneal staining, Schirmer scores).

Conclusions : These findings suggest dichotomous DE populations with regards to trigeminal somatosensory function, as subjects with more severe DE symptoms and ocular pain had maladaptive responses during and after prolonged noxious stimulation (i.e., central sensitization), while those with abnormal ocular signs exhibited more normative responses to prolonged noxious stimulation on the forehead.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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