September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Genetic signatures of rod and cone-dominant retinas and mouse models of retina degeneration
Author Affiliations & Notes
  • Krzysztof Palczewski
    Case Western Reserve Univ, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Krzysztof Palczewski, None
  • Footnotes
    Support  NIH GRant EY009339
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Krzysztof Palczewski; Genetic signatures of rod and cone-dominant retinas and mouse models of retina degeneration. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : The advent of high-throughput ‘–omics’ technologies for sequencing genomes and transcriptomes promises to provide a more complete picture of changes affecting organ and tissue homeostasis. RNA-Seq is a recently developed approach to transcriptome profiling that provides a more precise measurement of levels of transcripts and their isoforms than other methods. Pathological alterations could thus be more readily identified and pharmacologically corrected. Moreover, we performed RNA-Seq analysis with both retinal and RPE for large collections of animal models mimicking human retinopathies. We used also RNAseq to accurately verify their identities as derived from transgenic mice. A more complete picture of genetic signatures of rod and cone-dominant retinas and mouse models of retinal degeneration and before and after pharmacological will be presented.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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