September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Surgical feasibility of wide-field dual-array suprachoroidal–transretinal stimulation (STS) prosthesis in middle-sized animals
Author Affiliations & Notes
  • Takeshi Morimoto
    Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Hiroyuki Kanda
    Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Tomomitsu Miyoshi
    Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takao Endo
    Ophthalmology, Osaka Univ Graduate Sch of Med, Suita, Japan
  • Tibor Karl Lohmann
    Ophthatmology, Aachen RWTH Aachen University, Aachen, Germany
    Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Kohji Nishida
    Ophthalmology, Osaka Univ Graduate Sch of Med, Suita, Japan
  • Takashi Fujikado
    Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Footnotes
    Commercial Relationships   Takeshi Morimoto, None; Hiroyuki Kanda, None; Tomomitsu Miyoshi, None; Takao Endo, None; Tibor Lohmann, None; Kohji Nishida, None; Takashi Fujikado, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3719. doi:
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    • Get Citation

      Takeshi Morimoto, Hiroyuki Kanda, Tomomitsu Miyoshi, Takao Endo, Tibor Karl Lohmann, Kohji Nishida, Takashi Fujikado; Surgical feasibility of wide-field dual-array suprachoroidal–transretinal stimulation (STS) prosthesis in middle-sized animals. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3719.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the feasibility of implanting a newly developed wide-field dual-array suprachoroidal–transretinal stimulation (STS) prosthesis in healthy dogs and cats.

Methods : Three healthy dogs and three healthy cats were used in this study. The STS dual array consisted of two arrays with 25 electrodes. The arrays were implanted into a scleral pocket of each of three healthy beagle dogs and three healthy cats under general anesthesia. Color fundus photography and Optical coherence tomography (OCT) were performed postoperatively. The animals were euthanatized after the experimental period and the retinas were evaluated histologically.

Results : All the prostheses were successfully implanted without complications, and no serious complications occurred during the experimental period. The fixation of the implant was stable throughout the experimental period. Fundus photographs and OCT revealed no serious damage in the retina and choroid around the arrays.
Histologic evaluations showed good preservation of the retina over the electrode array.

Conclusions : Implantation of a newly developed wide-field dual-array STS retinal prosthesis into a scleral pocket of animals is surgically feasible and can be performed without significant damage to the retina or the animal. These findings indicate that it might be possible to implant more STS electrode arrays to cover a larger area of the retina to activate a larger visual field.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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