September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal reproducibility of spectral domain optical coherence tomography (SD-OCT) in children with stable glaucoma and physiological cupping
Author Affiliations & Notes
  • Limin Xu
    Duke University School of Medicine, Durham, North Carolina, United States
  • Mays El-Dairi
    Pediatric Ophthalmology, Duke Eye Center, Durham, North Carolina, United States
    Neuro-Ophthalmology, Duke Eye Center, Durham, North Carolina, United States
  • Evan Silverstein
    Department of Ophthalmology, Virginia Commonwealth University, Richmond, Virginia, United States
  • Sharon Freedman
    Pediatric Ophthalmology, Duke Eye Center, Durham, North Carolina, United States
    Glaucoma, Duke Eye Center, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Limin Xu, None; Mays El-Dairi, Knights Templar (F), Prana Pharmaceuticals (C); Evan Silverstein, None; Sharon Freedman, FocusROP (P), Inotek (C), Pfizer (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Limin Xu, Mays El-Dairi, Evan Silverstein, Sharon Freedman; Longitudinal reproducibility of spectral domain optical coherence tomography (SD-OCT) in children with stable glaucoma and physiological cupping. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Spectralis SD-OCT has previously shown good reproducibility for measurements of both peripapillary retinal nerve fiber layer (RNFL) and macular thickness in eyes of adults with known or suspected glaucoma, as well as in children with healthy eyes. However, few publications consider longitudinal reproducibility of SD-OCT in children.

Methods : This retrospective clinical study included 47 eyes of 47 children (age <18yrs) with stable primary congenital glaucoma (PCG), juvenile open-angle glaucoma (JOAG), and physiologic cupping (clinically diagnosed) having had ≥2 SD-OCT Spectralis (Heidelberg, Germany) studies over >1-year period. Thicknesses of average peripapillary Retinal Nerve Fiber Layer (RNFL) and six individual sectors, as well as volumes of 5 segmented retinal layers and total retina were measured using an 8×8 mm grid centered on the foveal pit. Spectralis review software was used for segmentation. Intraclass correlation coefficients (ICC) and coefficient of variation (COV) were calculated for each of the above OCT parameters.

Results : 31 eyes with glaucoma (20 PCG, 11 JOAG) and 16 eyes with physiologic cupping were included. For PCG, JOAG, and physiologic cupping, mean(±SD) ages at initial SD-OCT were 9.7±3.3, 13.3±2.0, and 11.0±3.3 years, respectively; mean times between first and last SD-OCTs were 3.0±1.4, 2.8±1.6, and 2.1±1.1 years, respectively. The intervisit ICCs for the average and sectoral RNFL thicknesses across three visits were 0.887-0.997 for all groups. Intervisit ICCs for segmented retinal layer volumes were 0.806-0.993 for all groups. Intervisit ICCs for total retinal volume for PCG, JOAG, and physiologic cupping across three visits were 0.954, 0.988, and 0.993, respectively. Intervisit COVs for average RNFL thickness were 1.7%, 2.6%, and 1.2% for PCG, JOAG, and physiologic cupping, respectively. For all other parameters, intervisit COV ranged from 0.4-6.7%.

Conclusions : The reproducibility of longitudinal SD-OCT measurements was very good (ICC>0.8) for all average and sectoral RNFL thicknesses, as well as for total and segmented retinal volumes. For average RNFL thickness, longitudinal reproducibility of SD-OCT in children with stable glaucoma over ~2 years is comparable to reported short-term reproducibility in children with normal eyes (1.16% COV) and adults with normal eyes and glaucoma (1.62-1.95% COV).

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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