September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Automated identification and quantification of subretinal fibrosis in neovascular age-related macular degeneration using polarization-sensitive optical coherence tomography
Author Affiliations & Notes
  • Philipp Ken Roberts
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Mitsuro Sugita
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Gabor Dèak
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Stefan Zotter
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Stefan Sacu
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Christoph K Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Philipp Roberts, Canon Inc. (F); Mitsuro Sugita, Canon Inc. (F); Gabor Dèak, None; Bernhard Baumann, Canon Inc. (F); Stefan Zotter, Canon Inc. (F); Michael Pircher, Canon Inc. (F); Stefan Sacu, None; Christoph Hitzenberger, Canon Inc. (C); Ursula Schmidt-Erfurth, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Philipp Ken Roberts, Mitsuro Sugita, Gabor Dèak, Bernhard Baumann, Stefan Zotter, Michael Pircher, Stefan Sacu, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Automated identification and quantification of subretinal fibrosis in neovascular age-related macular degeneration using polarization-sensitive optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 201657(12):.

      Download citation file:


      © 2017 Association for Research in Vision and Ophthalmology.

      ×
  • Supplements
Abstract

Purpose : To identify and quantify subretinal fibrosis in eyes with advanced neovascular age-related macular degeneration (AMD) using polarization-sensitive optical coherence tomography (PS-OCT).

Methods : Eyes of patients with subretinal or sub-retinal pigment epithelium (RPE) fibrosis secondary to neovascular AMD were included in this case series. All patients underwent a complete standardized ophthalmic examination to clearly identify advanced neovascular AMD lesions with scarring. PS-OCT examinations were performed using a novel PS-OCT system with an integrated eye-tracker allowing to selectively detect the intrinsic birefringence of collagenous fibres. Areas of fibrosis in PS-OCT, automatically segmented using a proprietary algorithm, were compared to conventional imaging modalities including spectral-domain OCT, fluorescein angiography (FA) and color fundus photography (CF) in their potential to visualize fibrotic scarring in AMD.

Results : Fifteen eyes of 15 consecutive patients with subretinal scarring secondary to advanced neovascular AMD were included. In PS-OCT B-scans, a distinct “column-like” pattern was observed in averaged axis orientation images, indicative of the specific orientation of collagenous fibers within the surrounding tissue. En face analysis provides a precise 3D mapping of the fibrotic scar component.
Fibrous tissue was selectively identified by PS-OCT based on birefringence in all lesions, whereas in SD-OCT subretinal hyperreflective material (SHRM) could not be further classified into scar tissue, fibrovascular material or other AMD-specific material. Based on simultaneous polarization analyses in PS-OCT, the level of RPE alteration could be evaluated as well, showing thinning and loss of RPE associated with subretinal fibrosis.

Conclusions : Using PS-OCT, subretinal fibrosis can be identified as an intrinsically birefringent structure and can be quantified based solely on its tissue-specific contrast. PS-OCT offers a unique method to identify clinically relevant components of SHRM (i.e. neovascular tissue vs. fibrous tissue) and therefore allow for an optimized disease management as well as evaluation of therapeutic strategies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×