September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Disconnection of ipsilateral FEF from the attention network in strabismic amblyopia during coherent motion task
Author Affiliations & Notes
  • Sheila Gillard Crewther
    School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia
  • Hao Wang
    Key Laboratory of Visual Damage and Regeneration and Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital,Third Military Medical University, Chongqing, China
  • Mingiong Liang
    Department of Radiology, Third Military Medical University, Chongqing, China
  • Tao Yu
    Key Laboratory of Visual Damage and Regeneration and Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital,Third Military Medical University, Chongqing, China
  • Jian Wang
    Department of Radiology, Third Military Medical University, Chongqing, China
  • David P Crewther
    Centre for Human Psychopharmacology, Swinburne University, Melbourne, Victoria, Australia
  • Robin Laycock
    School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia
  • Zheng Yin
    Key Laboratory of Visual Damage and Regeneration and Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital,Third Military Medical University, Chongqing, China
  • Footnotes
    Commercial Relationships   Sheila Crewther, None; Hao Wang , None; Mingiong Liang , None; Tao Yu, None; Jian Wang , None; David Crewther, None; Robin Laycock, None; Zheng Yin, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Sheila Gillard Crewther, Hao Wang, Mingiong Liang, Tao Yu, Jian Wang, David P Crewther, Robin Laycock, Zheng Yin; Disconnection of ipsilateral FEF from the attention network in strabismic amblyopia during coherent motion task. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Anecdotally it has been suggested that the amblopic eye of strabismic amblyopes is less able and slower to drive eye movments than the fellow eye. Thus we compared speed threshold performance and brain activation during motion salience and voluntary saccade tasks in adult strabismic amblyopes and controls.

Methods : Psychophysical speed thresholds for target detection were measured in 8 strabismic amblyopes and 8 normal participants prior to fMRI scanning of a motion salience task and a task requiring voluntary saccades to horizontal stimulus position changes. Activation and functional networks between ROIs including parietal-frontal attention network, Frontal Eye Fields and V1 were examined.

Results : Significantly impaired speed thresholds for target detection were seen through the strabismic amblyopic eye compared to thresholds through the fellow eye or control eyes when determining the direction of motion of the coherently moving dots task. BOLD activation in V1, IPS and FEF was also weaker for both tasks, following viewing through the amblyopic eye compared to activation through the fellow or control eyes. Correlational connections between key nodes of the visual attention network activated by the amblyopic eye were abnormal in the motion salience task, with the FEF ipsilateral to the amblyopic eye isolated from all other nodes. By contrast, the functional connections of this network were normal for the voluntary saccade task.

Conclusions : Lower motion thresholds and less BOLD activation of the parietofrontal network through the amblyopic eye indicate a requirement for longer exposure time for discrimination of the moving target during amblyopic eye driven movements compared to those through the fellow eye or control eyes. A specific deficit in functional connectivity was also seen between V1 and the frontal eye field ipsilateral to the strabismic eye during the motion salience task but not during the voluntary saccade task.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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