September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The Effect of Betadine on Vision.
Author Affiliations & Notes
  • Caren Oquindo
    Southern California College of Optometry, Marshall B. Ketchum University, Fullerton, California, United States
  • William H Ridder
    Southern California College of Optometry, Marshall B. Ketchum University, Fullerton, California, United States
  • Kavita Dhamdhere
    Allergan, Inc., Irvine, California, United States
  • James A Burke
    Allergan, Inc., Irvine, California, United States
  • Footnotes
    Commercial Relationships   Caren Oquindo, Allergan, Inc. (F); William Ridder, Allergan, Inc. (F); Kavita Dhamdhere, Allergan, Inc. (E); James Burke, Allergan, Inc. (E)
  • Footnotes
    Support  Allergan Inc
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3854. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Caren Oquindo, William H Ridder, Kavita Dhamdhere, James A Burke; The Effect of Betadine on Vision.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3854.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Betadine is instilled topically on the eye prior to ocular surgical procedures to decrease the risk of endophthalmitis. Its effects on functional vision and the cornea have not been determined. The purpose of this study was to determine the effects of 5% betadine on vision function, corneal integrity and subjective complaints.

Methods : Twenty subjects were chosen to participate in this study (Ten young: 25.8 +/- 2.94; and ten old: 58.2 +/- 5.59). LogMAR acuity, contrast sensitivity, corneal fluorescein staining, and the Schein dry eye questionnaire were measured before and after 60 µl of 5% betadine was applied to one eye, randomly chosen, (baseline, 5, 30, and 60 minutes and 4 and 24 hours post-application). Contrast sensitivity at 14 cpd was determined with a spatial two-alternative, forced choice procedure (BeethovenTM software). The NEI grid was used to grade corneal staining. Subjective complaints were monitored using the Schein dry eye questionnaire.

Results : The data were analyzed with an ANOVA (linear mixed-effects model). The logMAR acuity was significantly reduced from baseline at the 30 and 60 minute visits (all p values < 0.05) and contrast sensitivity was reduced from baseline at 5, 30, and 60 minutes after betadine application (all p values < 0.0001). Total corneal staining, maximum NEI sector staining, and the Schein dry eye questionnaire were significantly different from baseline at every visit (all p values < 0.05).

Conclusions : There was an increase in corneal staining and subjective complaints that lasted 24 hours and a decrease in functional vision that lasted 1 hour after 5% betadine instillation. The central corneal staining cleared more rapidly than the peripheral cornea; therefore, visual acuity recovered more quickly than overall corneal staining and subjective complaints. This may have resulted from pooling of Betadine at the limbus and lid margins. 5% Betadine application significantly affects corneal integrity which decreases functional vision and increases subjective complaints.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×