September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
HLA class I genes associated with Cold Medicine related Stevens-Johnson Syndrome with Severe Ocular Complications in the Brazilian population.
Author Affiliations & Notes
  • Tais Hitomi Wakamatsu
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • Mayumi Ueta
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Katsushi Tokunaga
    Department of Human Genetics, University of Tokyo, Tokyo, Japan
  • Yukinori Okada
    Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan
  • Renata Ruoco Loureiro
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • Karita Antunes Costa
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • Juliana M F Sallum
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • José Milhomens
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • Chie Sotozono
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Jose Alvaro Pereira Gomes
    Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  • Shigeru Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Footnotes
    Commercial Relationships   Tais Wakamatsu, None; Mayumi Ueta, None; Katsushi Tokunaga, None; Yukinori Okada, None; Renata Loureiro, None; Karita Costa, None; Juliana Sallum, None; José Milhomens, None; Chie Sotozono, None; Jose Alvaro Gomes, None; Shigeru Kinoshita, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3880. doi:
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      Tais Hitomi Wakamatsu, Mayumi Ueta, Katsushi Tokunaga, Yukinori Okada, Renata Ruoco Loureiro, Karita Antunes Costa, Juliana M F Sallum, José Milhomens, Chie Sotozono, Jose Alvaro Pereira Gomes, Shigeru Kinoshita; HLA class I genes associated with Cold Medicine related Stevens-Johnson Syndrome with Severe Ocular Complications in the Brazilian population.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3880.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-complex mediated hypersensitivity diseases that typically involve the skin and mucous membranes. Here we investigated etiologic factors such as causative drugs and the association between human leukocyte antigen (HLA) class I genes and cold medicine-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in Brazilian patients.

Methods : We enrolled 74 Brazilian patients with SJS/TEN with SOC and 135 healthy Brazilian volunteers. The patients' ethnicity was Pardo (51%), European ancestry (40%) and others. All were interviewed with respect to possible etiologic factors.
HLA class I (HLA-A, -B, -C) were examined to determine whether there was a genetic predisposition for CM-SJS/TEN with SOC.

Results : We identified cold medicine as the main causative drug (39 patients - 53%). HLA-A*66:01, HLA-B*44:03 and HLA-C*12:03 were associated, and HLA-A*11:01, HLA-B*08:01, and HLA-B*51:01 were inversely associated with Brazilian CM-SJS/TEN with SOC. After dividing in Pardo and European ancestry, HLA-A*66:01 was associated with among individuals both Pardo and European ancestry; HLA-B*44:03 and HLA-C*12:03 among individuals with only European ancestry.

Conclusions : In conclusion, our findings suggested that HLA-A*66:01 might be a marker in Pardo and European ancestry and HLA-B*44:03 and HLA-C*12:03 might be markers in only European ancestry. Moreover, HLA-A*11:01 might be a marker of resistance to CM-SJS/TEN with SOC.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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