September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma
Author Affiliations & Notes
  • Naoko Aizawa
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Yukihiro Shiga
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Satoru Tsuda
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Kazuko Omodaka
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Yu Yokoyama
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Tomoki Yasui
    Yasui eye clinic, Rifu, Japan
  • Keiichi Kato
    Kato eye center, Taiwa, Japan
  • Toru Nakazawa
    Ophthalmology, Tohoku University, Sendai, Miyagi, Japan
  • Footnotes
    Commercial Relationships   Naoko Aizawa, None; Yukihiro Shiga, None; Satoru Tsuda, None; Kazuko Omodaka, None; Yu Yokoyama, None; Tomoki Yasui, None; Keiichi Kato, None; Toru Nakazawa, Santen Pharmaceutical Co, Ltd (F)
  • Footnotes
    Support  JST grant from JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (T.N. 26293372), Exploratory Research (T.N. 26670751)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3900. doi:
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    • Get Citation

      Naoko Aizawa, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa; Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3900.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate visual field defect region and its deterioration speed in preperimetric glaucoma (PPG).

Methods : This study is a prospective observational study, which enrolled 93 eyes with PPG of 93 patients (a mean age of 53.6 ± 1.9 years). All patients had been prescribed topical taflprost for at least 16 months and underwent at least 5 visual field examinations. Mean deviation (MD) and total deviation (TD) were measured with standard automated perimetory (Humphrey 24-2 test program), and TD slopes were calculated in the six sectors, which were previously defined by the Garway-Heath map. Sector 1 corresponds to the temporal region of the optic nerve head, sector 2 superotemporal region, sector 3 superonasal region, sector 4 nasal region, sector 5 inferonasal region, and sector 6 inferotemporal region.

Results : There was no significant progression on total MD (P=0.193) and the total MD slope (dB/year) was -0.12±0.91 during follow up periods. There also was no progression on TD in sector 1, 2, 3, 4, and 6 (P=0.017, P=0.995, P=0.76, P=0.352, and P=0.080, respectively) and the TD slopes (dB/year) in each sector were -0.25±0.99, 0.00±0.98, -0.04±1.15, -0.11±1.15, and -0.18±0.99, respectively. However, There was a significant progression on TD in sector 5 (P=0.001) and the TD slope was -0.38±1.43.

Conclusions : We found that there is region difference on deterioration speed depend on visual field loss in PPG under administration of topical taflprost. TD slope analysis in the six sectors may be clinically efficient to detect progression in eyes with PPG.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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