September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Minimally important Differences in the NEI-VFQ 25: Data from the TVT study
Author Affiliations & Notes
  • Aachal Kotecha
    NIHR Biomedical Research Centre, UCL Institute of Ophthalmology & Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • William J Feuer
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Keith Barton
    NIHR Biomedical Research Centre, UCL Institute of Ophthalmology & Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Steven Gedde
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Aachal Kotecha, None; William Feuer, Abbott Medical Optics (F); Keith Barton, Abbott Medical Optics (F); Steven Gedde, None
  • Footnotes
    Support  The study was supported by an unrestricted grant from Abbott Medical Optics, Santa Ana, California
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3910. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Aachal Kotecha, William J Feuer, Keith Barton, Steven Gedde; Minimally important Differences in the NEI-VFQ 25: Data from the TVT study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3910.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To report the minimally important difference (MID) for the National Eye Institute-Visual Function Questionnaire (NEIVFQ-25) for the TVT study cohort.

Methods : The Tube Versus Trabeculectomy (TVT) study is a multicenter randomized clinical trial comparing tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in patients with previous ocular surgery. Patient reported outcomes were assessed using the vision-specific NEIVFQ-25. 202 of 207 patients enrolled in the study had NEIVFQ measured at baseline. Clinical measures included the mean deviation (MD; Humphrey 24-2 visual field) of the surgical eye, and logMAR visual acuity (VA) measurements. Approximately half these patients had surgery performed in their better acuity eye; thus data were stratified to ‘better’/ ‘worse’ eye MD. Distribution and clinical anchor based methods were used to determine MID ranges. For anchor-based calculations, clinically significant changes in anchor were defined as > 2dB MD and > 0.2 logMAR. MIDs were only calculated for if the correlation between anchor and NEIVFQ score exceeded 0.3.

Results : Correlations between composite score and clinical anchors exceeded 0.3 for surgical eye MD, better eye MD and better eye acuity. Mean [SD; range] values of anchors at baseline were: surgical eye MD = -16.6 [9.3; -32 to -0.5] dB; better eye MD = -15.0 [9.3; -32 to -0.9] dB; better eye acuity = 0.2 [0.3; -0.1 to 1.3] logMAR. For anchor-based cross sectional analysis, composite score MID [95%CI] was 6.3 [4.6 to 7.9] for better eye VA, 1.0 [0.6 to 1.4] for surgical eye MD and to 1.8 [1.2 to 2.5] for better eye MD. Distribution-based MIDs were 5.8 using 1/3 standard deviation of the composite score. MIDs for subscores were also calculated.

Conclusions : In this cohort of patients with advanced glaucoma, a range of MIDs for the NEIVFQ were found, some of which are comparable to results reported by other studies using the NEIVFQ. Distribution based MIDs corresponded well with anchor-based MIDs based on acuity measures.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×