September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Predicting Driving Performance using the Performance-Centered Portable Test (PERCEPT) in Patients with Glaucoma
Author Affiliations & Notes
  • Luciana Arias Fernandez
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
    Department of Ophthalmology, Federal University of São Paulo, Sao Paulo, Sao Paulo, Brazil
  • Alberto Diniz-Filho
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Carolina Pelegrini Gracitelli
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
    Department of Ophthalmology, Federal University of São Paulo, Sao Paulo, Sao Paulo, Brazil
  • Erwin R Boer
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Peter Rosen
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Augusto Paranhos Jr.
    Department of Ophthalmology, Federal University of São Paulo, Sao Paulo, Sao Paulo, Brazil
  • Felipe A Medeiros
    Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Luciana Fernandez, None; Alberto Diniz-Filho, None; Carolina Gracitelli, None; Erwin Boer, None; Peter Rosen, None; Augusto Paranhos Jr., None; Felipe Medeiros, Alcon Laboratories Inc. (F), Alcon Laboratories Inc. (R), Allergan Inc. (F), Allergan Inc. (R), Allergan Inc. (C), Baush & Lomb (F), Carl Zeiss Meditec Inc. (F), Carl Zeiss Meditec Inc. (R), Carl Zeiss Meditec Inc. (C), Heidelberg Engineering Inc. (F), Merck Inc. (F), National Eye Institute (F), Novartis (C), Reichert Inc. (R), Sensimed (F), Topcon Inc. (F)
  • Footnotes
    Support  NIH grant EY021818, core grant P30EY022589; fellowships from Brazilian National Council for Scientific and Technological Development (CNPq) 233829/2014-8 and Brazilian National Research Council (CAPES) 12309-13-3.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3912. doi:
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    • Get Citation

      Luciana Arias Fernandez, Alberto Diniz-Filho, Carolina Pelegrini Gracitelli, Erwin R Boer, Peter Rosen, Augusto Paranhos Jr., Felipe A Medeiros; Predicting Driving Performance using the Performance-Centered Portable Test (PERCEPT) in Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3912.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Performance-Centered Portable Test (PERCEPT) is a portable visual performance test investigating spatiotemporal and attentional mechanisms relevant to vision. The purpose of this study was to evaluate the ability of PERCEPT and standard automated perimetry (SAP) to predict simulated driving performance in patients with glaucoma.

Methods : This was a cross-sectional study involving 36 patients with bilateral glaucomatous visual field loss and 27 control healthy subjects. All subjects had SAP, driving simulation, and PERCEPT evaluation. The PERCEPT task consists in recognizing the orientation of a central tumbling E while also simultaneously identifying the position of a peripheral Gabor patch. The duration of stimulus presentation is progressively decreased until a reliable threshold for task performance can be obtained. Driving performance was evaluated on a driving simulator with curve negotiation and car following tasks. A summary index of driving performance was extracted through principal component analysis of simulator data. Linear regression models were used to evaluate the association between results from PERCEPT and objective driving performance and adjust for confounding variables.

Results : Mean age in the glaucoma and control groups was 68.3 ± 9.1 years vs. 55.5 ± 14.8 years, respectively (P<0.001). Average SAP mean deviation of the better and worse eye of glaucoma patients were -5.1 ± 7.1 dB and -9.1 ± 7.3 dB, respectively. PERCEPT processing speed was significantly higher (worse) in glaucoma patients compared to controls (688.1 ± 712.0 ms vs. 149.6 ± 303.6 ms, respectively; P<0.001). Simulated driving performance was significantly worse in glaucoma patients than controls (0.86 ± 3.38 vs. -0.89 ± 2.00; P=0.020). PERCEPT was more strongly associated with simulated driving performance (R2=35%; P<0.001) than SAP binocular MS (R2=20%; P<0.001). In a multivariable model adjusting for age, gender, and SAP binocular MS, PERCEPT processing speed was still significantly predictive of simulated driving performance (P=0.002).

Conclusions : PERCEPT was significantly predictive of driving performance as assessed on a driving simulator, providing additional information besides standard perimetry in predicting performance. These findings suggest that PERCEPT could be an effective test for evaluating functional performance in patients with glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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