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Manami Kuze, Masahiko Ayaki, Kazuo Tsubota, Mineo Kondo, Takeshi Morita; Electrophysiological function of intrinsically photosensitive retinal ganglion cells severely impaired in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3947.
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© ARVO (1962-2015); The Authors (2016-present)
Functional impairment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in glaucoma has been reported in pupil light reaction studies (Munich 2010). The aim of the present study was to evaluate the function of ipRGCs and to correlate this function with structural changes in the eye in glaucoma.
A four-primary illumination system (stimulus duration 250 ms) was used to stimulate ipRGCs independently of other photoreceptors (Fukuda 2012). Fifteen eyes from eight glaucoma patients (mean ± SD age 54.0±10.9 years) and eight eyes from eight healthy subjects (mean ± SD age 51.1±8.5 years; control group) were tested. Latencies were measured from stimulus onset and offset to the positive peaks, and amplitudes were measured from the baseline to the positive peaks. In addition, the thickness of the ganglion cell complex (GCC) was measured in glaucoma patients (Cirrus® HD-OCT; Carl Zeiss Meditec, Japan), as was the mean deviation (MD) of retinal sensitivity (Octopus® 900; Haag-Streit, Switzerland).
In the control group, two distinct positive peaks were recorded as on and off responses; these peaks were significantly reduced in the glaucoma group. The latencies of the on and off responses in glaucoma eyes (33.2±8.6 and 364.0±13.2 ms, respectively) prolonged significantly to those recorded for the control group (103.0±5.0 and 337.4±45.8 ms, respectively; P<0.05). In addition, the amplitude of the on and off responses was significantly lower in the glaucoma group (0.77±0.42 and 0.65±0.30 μV, respectively) than in the control group (7.7±2.8 and 7.3±3.4 μV, respectively; P<0.05). In the glaucoma group, the mean GCC was 55.7±14.5 mm and the mean MD was 15.2 ±8.9 dB. Decreases in GCC were correlated with all on and off amplitudes and latencies (P<0.001).
The results suggest that the electrophysiological function of ipRGCs is severely impaired in glaucoma.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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