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Daniel Glasser, Soratree Charoenthongtrakul, Hussein Wafapoor, Robert L Avery, Alexander M Eaton; Eye Drop Adherence Following Retina Surgery. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4000.
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© ARVO (1962-2015); The Authors (2016-present)
The goal of this observational study is to assess patient adherence to a prescribed ophthalmic drop regimen following retina surgery. Previous studies have shown that eye drop adherence is an issue for retina patients with visual impairment; however, none have evaluated eye drop delivery and compliance using a mobile video monitoring device. We hypothesize that that following retina surgery, patients will experience difficulty instilling their prescribed eye drops.
Twenty-seven subjects who had undergone retina surgery at the Retina Health Center were enrolled in the study on a consecutive basis. Subjects were trained on the use of the Eye Drop Application Monitor (EDAM) and their adherence was monitored for one week. Subjects recorded their adherence on a supplied take-home sheet where they noted the number of drops that landed in their eye, out of their eye, and/or half in/half out of their eye during each administration. The recorded videos were analyzed and percentages were calculated for actual treatment (drops in/prescribed), intention to treat (drops dispensed/prescribed), and success rate (drops in/dispensed). Drops analyzed as half in/half out were calculated as 0.5 drops in. A one-sample t-test was used to compare averages to the prescribed regimen. Averages represent the mean and standard deviation.
The actual drops delivered to the eye varied significantly from the prescribed regimen (p<0.005). Overall, subjects received 81% +/- 32% (range 4%-139%) of the drops they were prescribed. Their intention to treat (drops dispensed) was 125% +/- 38% (range 43%-211%) and was significantly different from prescribed regimen (p<0.005). The success rate per drop delivered was 69% +/- 30% (range 8%-100%) and varied significantly from an ideal success rate of 100% (p<0.001).
We found a statistically significant difference between patient’s prescribed eye drop regiment and what they delivered to their eye following retina surgery. While there are no standards for acceptable adherence rates, 20% variation from the regimen is generally the accepted deviation. When this acceptable rate is applied to all three criteria, only 37% (10 subjects) were successful at adhering to their prescribed regimen. Our study demonstrates there is a needed to improve eye drop delivery in retina patients following surgery.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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