September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The association between the presence of epiretinal membrane and nerve fiber layer defect in an adult Japanese population : The Chikusei Eye Study
Author Affiliations & Notes
  • Atsuro Uchida
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
  • Mariko Sasaki
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
    Ophthalmology, Tokyo Medical Center, Tokyo, Japan
  • Yoko Ozawa
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
  • Kaoru Motomura
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
  • Kenya Yuki
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
  • Kazumasa Yamagishi
    Public Health Medicine, University of Tsukuba, Tsukuba, Japan
  • Norie Sawada
    Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
  • Shoichiro Tsugane
    Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
  • Hiroyasu Iso
    Public Health, Social and Environmental Health, Osaka University Graduate School of Medicine, Osaka, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University School of Medicine , Tokyo, Japan
  • Footnotes
    Commercial Relationships   Atsuro Uchida, None; Mariko Sasaki, None; Yoko Ozawa, None; Kaoru Motomura, None; Kenya Yuki, None; Kazumasa Yamagishi, None; Norie Sawada, None; Shoichiro Tsugane, None; Hiroyasu Iso, None; Kazuo Tsubota, None
  • Footnotes
    Support  The waxman foundation of Japan
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4080. doi:
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      Atsuro Uchida, Mariko Sasaki, Yoko Ozawa, Kaoru Motomura, Kenya Yuki, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane, Hiroyasu Iso, Kazuo Tsubota; The association between the presence of epiretinal membrane and nerve fiber layer defect in an adult Japanese population : The Chikusei Eye Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4080.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the association between the presence of epiretinal membrane (ERM) and glaucomatous fundus changes, such as glaucomatous optic disc cupping and nerve fiber bundle defect (NFLD), in a Japanese population.

Methods : A cross-sectional community survey was conducted among residents of Chikusei in Ibaraki prefecture, Japan. A total of 1988 participants aged 40 years or older underwent non-mydriatic fundus photographs of both eyes, and ERM and glaucomatous fundus changes, such as glaucomatous optic disc cupping (cup disc ratio ≥ 0.7) and NFLD, were graded by experienced ophthalmologists. After excluding eyes with suboptimal fundus image quality or concomitant retinal diagnoses, the remaining 3803 eyes (mean age 62.9 ± 10.2 years) were included in this analysis. The associations between the presence of ERM and glaucomatous fundus changes were assessed using generalized estimating equation and expressed as odds ratios (ORs) with 95% confidence intervals (CI). Further analyses were performed separately for the two groups aged ≥ 60 and < 60 years.

Results : Of the study participants, ERM, glaucomatous optic disc cupping and NFLD were found in 12.9%, 16.7% and 10.9%, respectively. After adjusting for age, gender and refractive errors, ERM was positively associated with NFLD in participants aged ≥ 60 years (ORs: 1.54, 95%CI: 1.02, 2.32), whereas no association was found in participants aged < 60 years. There was no significant association between ERM and glaucomatous optic disc cupping in either age group.

Conclusions : The presence of ERM was associated with NFLD, but not glaucomatous optic disc cupping in this study sample. Longitudinal studies are warranted to confirm this observation and, if so, to elucidate the pathological mechanisms.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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