September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Thickening of retinal layers in anterior uveitis in the absence of macular edema and epiretinal membranes
Author Affiliations & Notes
  • Rafael S Grajewski
    Department of Opthalmology, University Eye Clinic Cologne, Cologne, Germany
  • Katja Burian
    Department of Opthalmology, University Eye Clinic Cologne, Cologne, Germany
  • Claus Cursiefen
    Department of Opthalmology, University Eye Clinic Cologne, Cologne, Germany
  • Ludwig M Heindl
    Department of Opthalmology, University Eye Clinic Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships   Rafael Grajewski, None; Katja Burian , None; Claus Cursiefen, None; Ludwig Heindl, None
  • Footnotes
    Support  German Research Foundation (FOR 2242 “(Lymph) Angiogenesis And Cellular Immunity In Inflammatory Diseases Of The Eye” GR 2647/5-1
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4121. doi:
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    • Get Citation

      Rafael S Grajewski, Katja Burian, Claus Cursiefen, Ludwig M Heindl; Thickening of retinal layers in anterior uveitis in the absence of macular edema and epiretinal membranes
      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):4121.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate central thickness (CT) of all retinal layers in patients with unilateral anterior uveitis devoid of macular edema and epiretinal membranes.

Methods : 206 eyes of 103 consecutive patients with unilateral anterior uveitis without macular edema and epiretinal membranes, underwent standardized macular examination using spectral-domain optical coherence tomography (SD-OCT; Heidelberg Engineering, Germany) and measurement of the total retinal layer, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), inner retinal layers (IRL), and the photoreceptor layer in comparison to the unaffected fellow eyes.

Results : In uveitis affected eyes central thickness of the total retinal layer (p<0.001), RNFL (p<0.001), GCL (p<0.001), IPL (p<0.001), INL (p<0.001), OPL (p<0.001), ONL (p=0.002), and IRL (p<0.001) was significantly higher than in the unaffected fellow eyes. In contrast, RPE (p=0.009) and the photoreceptor layer (p<0.001) were significantly lower in uveitis affected eyes compared to unaffected fellow eyes.

Conclusions : In anterior uveitis devoid of macular edema and epiretinal membrane formation all retinal layers, except the RPE and the photoreceptor layer, were thickened in comparison to the unaffected fellow eye. These changes could reflect a precursor state of potential macular complications in the later course of anterior uveitis, such as edema. Therefore, prospective studies are recommended to evaluate the predictive value of retinal thickness in anterior uveitis for secondary macular complications.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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