September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Juvenile idiopathic arthritis – associated uveitis: occurrence and course of ocular hypotony
Author Affiliations & Notes
  • Arnd Heiligenhaus
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
    University of Duisburg-Essen, Essen, Germany
  • Michael Böhm
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
    Department of Ophthalmology, University Clinic, Essen, Germany
  • Christoph Tappeiner
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
    Department of Ophthalmology, Inselspital, University, Bern, Switzerland
  • Mark Breitbach
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
  • Beatrix Zurek-Imhoff
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
  • Carsten Heinz
    Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany
    University of Duisburg-Essen, Essen, Germany
  • Footnotes
    Commercial Relationships   Arnd Heiligenhaus, None; Michael Böhm, None; Christoph Tappeiner, None; Mark Breitbach, None; Beatrix Zurek-Imhoff, None; Carsten Heinz, None
  • Footnotes
    Support  BMBF 01ER0812 and 01ER1504C, and DFG FOR 2240
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4133. doi:
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      Arnd Heiligenhaus, Michael Böhm, Christoph Tappeiner, Mark Breitbach, Beatrix Zurek-Imhoff, Carsten Heinz; Juvenile idiopathic arthritis – associated uveitis: occurrence and course of ocular hypotony. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4133.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze occurrence, risk factors and course of ocular hypotony (OH) in juvenile idiopathic arthritis-associated uveitis (JIAU).

Methods : Cross-sectional, retrospective study of JIAU patients with and without ocular hypotony. Epidemiological and ophthalmological data at baseline and during follow-up were evaluated.

Results :
OH occurred in 57 of the 365 JIAU patients (mean follow-up of 3.5±3.5 years). In 40 of the patients, OH was not related to previous ocular surgery: Baseline risk factors for OH during clinical course (univariate logistic regression analysis) included higher age at onset of uveitis (OR 1.15 p=0.003), bilateral uveitis (OR 3.51, p=0.009), low visual acuity (OR 5.1, p=0.001), and high anterior chamber (AC) – laser-flare values (LF; OR 1.74, p=0.01). Increased AC-cell- and -LF- values were observed within three months prior to onset of transient (≤3 months; 37.5%) or persistent OH (≥4 months; 62.5%). AC-cell- and -LF- values decreased within 3 months after onset of transient OH, while LF levels remained elevated ≥12 months in persistent OH. Optic disc edema and epiretinal membrane formation was found more often after OH onset.

Conclusions : OH was observed in 15.6% of JIAU patients. Higher age at uveitis onset, bilateral uveitis, low visual acuity, and high AC-cell- and –laser-flare-grades at baseline were risk factors for subsequent OH. Systemic immunosuppression reduced the risk for OH occurrence, and improved the OH course.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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