September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Significance of Choroidal Hyper-reflective foci visualised on Enhanced Depth Imaging in Central Serous Chorioretinopathy
Author Affiliations & Notes
  • Namritha Valerie Patrao
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Deepthy Menon
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Marta Zola
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Priyanka Sanghi
    Institute of Ophthalmology, University College of London, London, United Kingdom
  • Luke Nicholson
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Philip Hykin
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Sobha Sivaprasad
    NIHR Moorfields Biomedical Research Centre, London, United Kingdom
  • Footnotes
    Commercial Relationships   Namritha Patrao, None; Deepthy Menon, None; Marta Zola, None; Priyanka Sanghi, None; Luke Nicholson, None; Philip Hykin, Allergan (F), Allergan (C), Bayer (F), Bayer (C), Novartis (F), Novartis (C); Sobha Sivaprasad, Allergan (F), Allergan (C), Bayer (F), Bayer (C), Novartis (F), Novartis (C), Roche (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4234. doi:
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      Namritha Valerie Patrao, Deepthy Menon, Marta Zola, Priyanka Sanghi, Luke Nicholson, Philip Hykin, Sobha Sivaprasad; Significance of Choroidal Hyper-reflective foci visualised on Enhanced Depth Imaging in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4234.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Central serous chorioretinopathy (CSC) is believed to be due to abnormal and increased choroidal hyperpermeability and is clinically represented as increased choroidal thickness on optical coherence tomography (OCT). Hyper-reflective foci (HRF) are observed within the choroid in CSC, but the significance of HRF in CSC remains unclear. The aim of this study was to assess the factors associated with the presence of HRF in recurrent and chronic CSC.

Methods : We retrospectively graded the enhanced depth imaging (EDI) scans of consecutive patients with CSC and evaluated the association of HRF with demographic data, subfoveal thickness of the choroid, presence or absence of the choriocapillaris layer and integrity of the ellipsoid layer.

Results : We evaluated the EDI scans of 126 eyes of 99 patients with CSC with a mean age of 53.48 (±10.54) years. CSC was defined as recurrent in 36(29%) and chronic in 90 (71%) eyes. The mean subfoveal choroidal thickness was 403.37(±125.36)µm. HRF were more prevalent with increasing age (p=0.01). HRF were observed in 36(28.57%) and ellipsoid layer disruption was noted in 41(32.54%) eyes. HRF were present in 46.34% (p=0.003) of eyes with ellipsoid layer disruption. There was no significant association between HRF and gender (p=0.37), or absence of choriocapillaris (p=0.84).

Conclusions : Choroidal HRF in CSC were associated with the disruption of the photoreceptor layer suggesting that HRF may be a surrogate marker of poor photoreceptor function.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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