September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Type 2 diabetes mellitus patients with white dots in the central fundus and neuroretinal degeneration
Author Affiliations & Notes
  • Stanley Darma
    Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
  • Reinier O. Schlingemann
    Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
  • Pauline Kok
    Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
  • Michael David Abramoff
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
  • Frits Holleman
    Internal Medicine, Academic Medical Centre, Amsterdam, Netherlands
  • Frank D Verbraak
    Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
    Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, Netherlands
  • Footnotes
    Commercial Relationships   Stanley Darma, None; Reinier Schlingemann, None; Pauline Kok, None; Michael Abramoff, None; Frits Holleman, None; Frank Verbraak, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4238. doi:
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      Stanley Darma, Reinier O. Schlingemann, Pauline Kok, Michael David Abramoff, Frits Holleman, Frank D Verbraak; Type 2 diabetes mellitus patients with white dots in the central fundus and neuroretinal degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4238.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the relation between diabetic retinopathy (DR), neuroretinal degeneration and the presence of white dots in the central fundus in patients with type 2 diabetes mellitus (DM)

Methods : Patients with type 2 DM underwent SD-OCT 3D volume scanning of the optic disc and macular area, (Topcon 3D OCT-2000, Topcon Medical Systems) and redfree fundus fotography. We scored DR (ICDR classification) and the presence of small white dots (approximate diameter 10 micron) scattered around the fovea seen on redfree fundus photography. Peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer (mGCL), and macular inner retinal layer (mIRL) thickness were measured using the Iowa Reference Algorithm to measure neuroretinal degeneration. Metabolic control was taken from the patient record. Statistical analysis was done using linear mixed models.

Results : 155 type 2 DM patients were included in the study. In 64 patients (41%) there were more than 5 white dots in the central fundus. We found no significant difference in pRNFL , mGCL or mIRL thickness between type 2 DM patients with or without white dots in the central fundus.
Mean pRNFL thickness was 96±12 vs. 96±13 (p=0.619), mean mGCL thickness 45±8 vs. 45±8 (p=0.787) and mean mIRL thickness 107±12 vs. 109±13 (p=0.212).
No significant difference was found between type 2 DM patients with or without white dots in the presence of minimal DR (p=0.61) and levels of HbA1c, creatinine and lipid profile.

Conclusions : White dots in the ocular fundus of type 2 DM patients do not have a relation with neuroretinal degeneration measured with SD-OCT, nor with the presence of DR or metabolic control.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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