September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Correlation of Indocyanine Green Angiography and Optical Coherence Tomography in Polypoidal Choroidal Vasculopathy
Author Affiliations & Notes
  • Tarek Alasil
    Ophthalmology and Visual Sciences, Yale University, New Haven, Connecticut, United States
  • Nelida Munoz sanz
    Ophthalmology and Visual Sciences, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Andrew Keane
    Ophthalmology and Visual Sciences, Moorfields Eye Hospital, London, United Kingdom
  • Patrick Coady
    Ophthalmology and Visual Sciences, Yale University, New Haven, Connecticut, United States
  • Adnan Tufail
    Ophthalmology and Visual Sciences, Moorfields Eye Hospital, London, United Kingdom
  • Ron A Adelman
    Ophthalmology and Visual Sciences, Yale University, New Haven, Connecticut, United States
  • Footnotes
    Commercial Relationships   Tarek Alasil, None; Nelida sanz, None; Pearse Keane, None; Patrick Coady, None; Adnan Tufail, None; Ron Adelman, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4259. doi:
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      Tarek Alasil, Nelida Munoz sanz, Pearse Andrew Keane, Patrick Coady, Adnan Tufail, Ron A Adelman; Correlation of Indocyanine Green Angiography and Optical Coherence Tomography in Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4259.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To correlate indocyanine green angiography (ICGA) and optical coherence tomography (OCT) findings in patients with polypoidal choroidal vasculopathy (PCV).

Methods : 110 eyes of 110 subjects with ICGA confirmed PCV were included in a retrospective multicenter cross-sectional study. PCV patients were recruited from the United States and the United Kingdom. The location of the polypoidal lesions was identified on ICGA. OCT features were identified and recorded including the presence/abscence of pigment epithelial detachments (PEDs), subretinal fluid (SRF), interruption of the inner segment-outer segement (IS-OS) junction of the photoreceptors, branching vascular network (BVN), and fibrovascular scarring.

Results : The 110 subjects included in our analysis had an average age of 69.5 ± 10 years. Of the 110 PCV subjects, 69 (63%) were women. Best corrected visual acuity was 64 ± 20 letters (ETDRS letter count). All subjects had polypoidal lesions seen on ICGA in order to establish the diagnosis. Utilizing OCT, PED was found in 95/110 (86%) and SRF was demonstrated in 79/110 (72%). Interruption of the IS-OS junection was observed in 101/110 (92%) and BVN was reported in 85/110 (77%). Fibrovascular scarring was noted in 35/110 (32%). Correlation of OCT features with ICGA findings was consistent with the presence of polyps on the edge of the PED in 65/110 (59%), which appeared as notching of the edge of the PED in 53% of cases. The BVN seen on ICGA was correlated with the double layer sign on OCT in 75/110 (68%).

Conclusions : OCT features can be correlated with ICGA findings in patients with PCV. While ICGA remains the gold standard for diagnosing PCV, OCT can provide an additional tool to establish and solidify the diagnosis of PCV.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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